Establishment and application of methodologies for optimizing imaging techniques in digital radiology

• Grant number: 15/21873-8
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2016
• End date: October 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Alessandra Tomal
• Grantee: Alessandra Tomal
• Host Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Associated researchers: Beatriz Regina Alvares ; Mario Antonio Bernal Rodriguez ; Nestor de Barros ; Paulo Roberto Costa ; Rodrigo Menezes Jales

Abstract

Diagnostic radiology has experienced remarkable advances in the last decades, with the development of digital image receptors. The migration of conventional to digital radiology is resulting of the advantages of digital detectors, resulting in a better image quality. However, optimization studies should be performed in order to identify conditions that provide the best image quality, while reducing the radiation dose absorbed by the patient. The main scope of this project is to establish a methodology for studying the optimal exposure parameters for different x-ray imaging examinations, through the implementation of a research laboratory of x-ray medical imaging and dosimetry. This project includes the optimization study of digital radiology, covering basically four different radiographic examinations: general digital radiology (chest radiography and orthopedic), digital mammography and pediatric radiology. In all cases, the dosimetric and image quality study will be performed by Monte Carlo simulation and experimentally. In clinical x-ray equipments, the method for optimization studies will be implemented and tested. This study will allow the identification of conditions that can improve the quality of the image obtained, and reducing risk to the patient's exposure to ionizing radiation. Besides, digital image receptors will be l characterized, in order to evaluate the most appropriate for each radiographic examination. Thus, this project is directly related to the research area of Radiation Physics and Dosimetry in Medical Physics. Besides, its development will contribute to the strengthening of Researches in medical physics developed at Applied Physics Department of the of Physics Gleb Wataghin of UNICAMP, especially the Medical Radiological Physics Group (GFRMd). (AU)

Scientific publications

(34)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSALES, LISET DE LA FUENTE; INCERTI, SEBASTIEN; FRANCIS, ZIAD; BERNAL, MARIO A.. Accounting for radiation-induced indirect damage on DNA with the Geant 4-DNA code. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 51, p. 108-116, JUL 2018. (15/21873-8, 11/51594-2)

SANTOS, JOSILENE C.; TOMAL, ALESSANDRA; DE BARROS, NESTOR; COSTA, PAULO R.. Normalized glandular dose (DgN) coefficients from experimental mammographic x-ray spectra. Physics in Medicine and Biology, v. 64, n. 10, MAY 2019. (13/07117-0, 10/12237-7, 15/21873-8)

LI, WEI BO; STANGL, STEFAN; KLAPPROTH, ALEXANDER; SHEVTSOV, MAXIM; HERNANDEZ, ALICIA; KIMM, MELANIE A.; SCHUEMANN, JAN; QIU, RUI; MICHALKE, BERNHARD; BERNAL, MARIO A.; et al. Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy-Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling. CANCERS, v. 13, n. 21, NOV 2021. (15/21873-8, 20/08647-7, 11/51594-2, 18/15316-7)

FRANCIS, Z.; MONTAROU, G.; INCERTI, S.; BERNAL, M.; ZEIN, S. A.. A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 67, p. 148-154, NOV 2019. (11/51594-2, 18/15316-7, 15/21873-8)

MAGALHAES, D. P.; RINKEL, J.; TOMAL, A.. Radiation damage impact on hybrid-pixel detectors data. Radiation Physics and Chemistry, v. 160, p. 63-67, JUL 2019. (15/21873-8, 11/51594-2)

MASSERA, RODRIGO T.; TOMAL, ALESSANDRA. Breast glandularity and mean glandular dose assessment using a deep learning framework: Virtual patients study. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 83, p. 264-277, MAR 2021. (15/21873-8)

MENDES, H.; TOMAL, A.. Implementation of Detailed Monte Carlo Simulation for Semiconductor Detectors Using the PENELOPE Code. Medical Physics, v. 48, n. 6, p. 1-pg., 2021-06-01. (15/21873-8)

BERNAL, MARIO A.; LIENDO, JACINTO A.; INCERTI, SEBASTIEN; FRANCIS, ZIAD; TRAN, HOANG N.. Experimental cross sections for water ionization due to the impact of light ions-A review. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIO, v. 517, p. 10-pg., 2022-04-15. (11/51594-2, 18/15316-7, 15/21873-8, 20/08647-7)

MAGALHAES, D. P.; TOMAL, A.. Monte Carlo simulation of hybrid pixel detectors. Radiation Physics and Chemistry, v. 167, FEB 2020. (11/51594-2, 15/21873-8)

DE FARIA, JHAISON C.; PAUPITZ, RICARDO; VAN DUIN, ADRI C. T.; BERNAL, MARIO A.. Evaluation of the Reax Force-Field for Studying the Collision of an Energetic Proton with the DNA. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. 18, n. 11, p. 9-pg., 2022-11-08. (11/51594-2, 18/15316-7, 15/21873-8, 20/08647-7)

SHIN, WOOK-GEUN; SAKATA, DOUSATSU; LAMPE, NATHANAEL; BELOV, OLEG; TRAN, NGOC HOANG; PETROVIC, IVAN; RISTIC-FIRA, ALEKSANDRA; DORDEVIC, MILOS; BERNAL, MARIO A.; BORDAGE, MARIE-CLAUDE; et al. A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. CANCERS, v. 13, n. 19, OCT 2021. (18/15316-7, 15/21873-8, 11/51594-2, 20/08647-7)

DE FARIA, JHAISON C.; PAUPITZ, RICARDO; VAN DUIN, ADRI C. T.; BERNAL, MARIO A.. Evaluation of the Reax Force-Field for Studying the Collision of an Energetic Proton with the DNA. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. N/A, p. 9-pg., 2022-10-28. (15/21873-8, 20/08647-7, 18/15316-7, 11/51594-2)

MASSERA, RODRIGO T.; THOMSON, ROWAN M.; TOMAL, ALESSANDRA. Technical note: MC-GPU breast dosimetry validations with other Monte Carlo codes and phase space file implementation. Medical Physics, v. 49, n. 1, NOV 2021. (18/05982-0, 15/21873-8, 16/15366-9)

MACHADO, ALINE Y.; RODRIGO, T. MASSERA; TOMAL, ALESSANDRA. Pipeline to generate synthesized mammographic images: reliability of a new framework for data augmentation-based ray-tracing method, Monte Carlo simulation, and deep learning scatter estimation. MEDICAL IMAGING 2025: PHYSICS OF MEDICAL IMAGING, PT 1, v. 13405, p. 6-pg., 2025-01-01. (18/05982-0, 15/21873-8, 21/08923-7, 23/03535-4)

MASSERA, RODRIGO T.; TOMAL, ALESSANDRA; THOMSON, ROWAN M.. Multiscale Monte Carlo simulations for dosimetry in x-ray breast imaging: Part II - Microscopic scales. Medical Physics, v. 51, n. 2, p. 10-pg., 2023-12-26. (15/21873-8, 21/08923-7, 18/05982-0)

TREVISAN MASSERA, R.; THOMSON, R.; TOMAL, A.. Implementing a Phase Space File Framework in MCGPU. Medical Physics, v. 47, n. 6, p. 1-pg., 2020-06-01. (15/21873-8)

BALLARINI, F.; CARANTE, M. P.; CAJIAO, J. J. TELLO; BERNAL, M. A.. Biophysical modelling of proximity effects in chromosome aberration production. NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS, v. 41, n. 6, NOV-DEC 2018. (11/51594-2, 15/21873-8)

SAKATA, DOUSATSU; LAMPE, NATHANAEL; KARAMITROS, MATHIEU; KYRIAKOU, IOANNA; BELOV, OLEG; BERNAL, MARIO A.; BOLST, DAVID; BORDAGE, MARIE-CLAUDE; BRETON, VINCENT; BROWN, JEREMY M. C.; et al. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 62, p. 152-157, JUN 2019. (15/21873-8, 11/51594-2)

ZABIHI, AZAM; TELLO, JOHN; INCERTI, SEBASTIEN; FRANCIS, ZIAD; FOROZANI, GHASEM; SEMSARHA, FARID; MOSLEHI, AMIR; BERNAL, MARIO A.. Determination of fast neutron RBE using a fully mechanistic computational model. Applied Radiation and Isotopes, v. 156, FEB 2020. (11/51594-2, 18/15316-7, 15/21873-8)

SAKATA, DOUSATSU; HIRAYAMA, RYOICHI; SHIN, WOOK-GEUN; BELLI, MAURO; TABOCCHINI, MARIA A.; STEWART, ROBERT D.; BELOV, OLEG; BERNAL, MARIO A.; BORDAGE, MARIE-CLAUDE; BROWN, JEREMY M. C.; et al. Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 105, p. 9-pg., 2022-12-20. (18/15316-7, 15/21873-8, 20/08647-7, 11/51594-2)

TANG, NICOLAS; BUENO, MARTA; MEYLAN, SYLVAIN; PERROT, YANN; TRAN, HOANG N.; FRENEAU, AMELIE; DOS SANTOS, MORGANE; VAURIJOUX, AURELIE; GRUEL, GAETAN; BERNAL, MARIO A.; et al. Assessment of Radio-Induced Damage in Endothelial Cells Irradiated with 40 kVp, 220 kVp, and 4 MV X-rays by Means of Micro and Nanodosimetric Calculations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 24, DEC 2019. (11/51594-2, 18/15316-7, 15/21873-8)

MASSERA, RODRIGO T.; FERNANDEZ-VAREA, JOSE M.; TOMAL, ALESSANDRA. Impact of photoelectric cross section data on systematic uncertainties for Monte Carlo breast dosimetry in mammography. Physics in Medicine and Biology, v. 66, n. 11, JUN 7 2021. (16/15366-9, 15/21873-8)

TREVISAN MASSERA, RODRIGO; TOMAL, ALESSANDRA. Estimation of glandular dose in mammography based on artificial neural networks. Physics in Medicine and Biology, v. 65, n. 9, MAY 7 2020. (16/15366-9, 15/21873-8)

DE OLIVEIRA, LUCA A.; DE FARIAS, JHAISON C.; BERNAL, MARIO A.. Combination of the TD-DFT and the pixel counting method for determining electron capture cross sections for protons impacting on organic molecules. EUROPEAN PHYSICAL JOURNAL D, v. 78, n. 12, p. 11-pg., 2024-12-01. (15/21873-8, 18/15316-7, 11/51594-2, 20/08647-7)

SENIWAL, BALJEET; BERNAL, MARIO A.; FONSECA, TELMA C. F.. Microdosimetric calculations for radionuclides emitting beta and alpha particles and Auger electrons. Applied Radiation and Isotopes, v. 166, DEC 2020. (18/15316-7, 15/21873-8, 11/51594-2)

DE FARIA, JHAISON C.; SANTIAGO, JOAO; FRANCIS, ZIAD; BERNAL, MARIO A.. Time-Dependent Density-Functional Theory for Determining the Electron-Capture Cross Section for Protons Impacting on Atoms and Molecules. Journal of Physical Chemistry A, v. 127, n. 11, p. 7-pg., 2023-03-14. (15/21873-8, 18/15316-7, 11/51594-2, 20/08647-7)

SEIF, EDGARD; EL BITAR, ZIAD; INCERTI, SEBASTIEN; BERNAL, MARIO A.; FRANCIS, ZIAD. Electron tracks simulation in water: Performance comparison between GPU CPU and the EUMED grid installation. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 104, p. 11-pg., 2022-11-08. (11/51594-2, 15/21873-8, 20/08647-7)

MENDES, HITALO RODRIGUES; TOMAL, ALESSANDRA. THOR: Inclusion of charge carriers' creation and transport in semiconductor detectors in the PENELOPE Monte Carlo simulation code. Radiation Physics and Chemistry, v. 229, p. 11-pg., 2024-12-04. (15/21873-8, 18/05982-0, 21/08923-7, 23/03535-4)

SANTIAGO, JOAO; DE FARIA, JHAISON C.; SAN-MIGUEL, MIGUEL; BERNAL, MARIO A.. A TD-DFT-Based Study on the Attack of the OH center dot Radical on a Guanine Nucleotide. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 17, p. 9-pg., 2022-09-01. (20/02348-8, 18/15316-7, 15/21873-8, 20/08647-7, 11/51594-2)

MASSERA, RODRIGO T.; TOMAL, ALESSANDRA; THOMSON, ROWAN M.. Multiscale Monte Carlo simulations for dosimetry in x-ray breast imaging: Part I - Macroscopic scales. Medical Physics, v. 51, n. 2, p. 12-pg., 2023-12-29. (15/21873-8, 21/08923-7, 18/05982-0)

MASSERA, RODRIGO TREVISAN; TOMAL, ALESSANDRA. Skin models and their impact on mean glandular dose in mammography. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v. 51, p. 38-47, JUL 2018. (16/15366-9, 15/21873-8)

SANTOS, JOSILENE C.; TOMAL, ALESSANDRA; FURQUIM, TANIA A.; FAUSTO, AGNES M. F.; NOGUEIRA, MARIA S.; COSTA, PAULO R.. Direct measurement of clinical mammographic x-ray spectra using a CdTe spectrometer. Medical Physics, v. 44, n. 7, p. 3504-3511, JUL 2017. (13/07117-0, 15/21873-8, 10/12237-7)

MAGALHAES, D. P.; RINKEL, J.; TOMAL, A.. Radiation damage impact on hybrid-pixel detectors data (Reprinted from Radiation Physics and Chemistry, vol 160, pg 63-67, 2019). Radiation Physics and Chemistry, v. 167, p. 5-pg., 2020-02-01. (15/21873-8, 11/51594-2)

TREVISAN MASSERA, R.; TOMAL, A.; THOMSON, R.. Multiscale Monte Carlo Simulations for Advanced X-Ray Breast Imaging: Dosimetric Studies. Medical Physics, v. 47, n. 6, p. 2-pg., 2020-06-01. (15/21873-8)