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Osteosarcopenic obesity: Crosstalk between osteoporosis, vitamin D, dietary intake and bone fracture risk

Grant number: 15/07971-7
Support Opportunities:Regular Research Grants
Duration: June 01, 2016 - May 31, 2018
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal Investigator:Lígia Araújo Martini
Grantee:Lígia Araújo Martini
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Bárbara Santarosa Emo Peters ; Regina Mara Fisberg ; Simone Aparecida dos Santos Conceicao Faria


Introduction: Osteosarcopenic obesity is characterized by a concurrent appearance of obesity in individuals with low bone and muscle mass. It seems to exert a synergistic impact on elderly performance and life quality and expectancy. In the recent years, a plentiful vitamin D extra skeletal benefits has been recognized. Considering it´s interrelation with bone, muscle and fat mass, we hypothesized that vitamin D plays an important role in the etiology of the osteosarcopenic obesity. Aims: to investigate the physiological and genomic mechanisms by which vitamin D could interact with osteosarcopenic obesity in adults and elderly. Methods: This is a cross-sectional study, including adults and elderly individuals from the ISA - Capital study (Inquérito de Saúde do Adulto, a population based study conducted in Sao Paulo). A total of 600 individuals (300 adults and 300 elderly) will be invited to a participate in this arm of the ISA-Capital. The data collection will comprise 5 phases; 1) application of questionnaires: age, sex, ehtina, socio economic characteristics, anthropometrical data, clinical history,dietary intake, sun exposure; 2) blood collection and a second dietary recall; 3) Body composition evaluation by DXA (Dual Energy X-ray Absorptiometry, iDXA GE Healthcare®), walk-and go and handgrip strength tests; 4) Energy expenditure test that will be performed in 51 elderly with the diagnose of obesity, sarcopenia, sarcopenic obesity an osteosarcopenic obesity; 5) biochemical measurements of 25(OH)D, PTH, polymorphisms on genes related to vitamin D metabolism (vitamin D receptor, vitamin D binding protein, and 7 - dehydrocholesterol). The statistical analysis will include mean differences, correlation, and qui-square tests. The regression analysis and general linear model will be used to determine the interplay between vitamin D and body composition variables. The study will be conducted after the approval of the Ethics Committee - FSP - USP. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FRANCA, NATASHA A. G.; PETERS, BARBARA S. E.; DOS SANTOS, ELIZABETE A.; LIMA, MARCELA M. S.; FISBERG, REGINA M.; MARTINI, LIGIA ARAUJO. Obesity Associated with Low Lean Mass and Low Bone Density Has Higher Impact on General Health in Middle-Aged and Older Adults. JOURNAL OF OBESITY, v. 2020, . (15/07971-7, 14/26787-0)
ELIZABETE A. DOS SANTOS; KELLY V. GIUDICI; NATASHA A. G. DE FRANÇA; BARBARA S. EMO PETERS; REGINA MARA FISBERG; LÍGIA A. MARTINI. Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 64, n. 4, p. 436-444, . (15/07971-7, 12/22113-9)
GIUDICI, KELLY VIRECOULON; GRANDE DE FRANCA, NATASHA APARECIDA; EMO PETERS, BARBARA SANTAROSA; FISBERG, REGINA MARA; MARTINI, LIGIA ARAUJO. Associations between markers of glucose metabolism and bone measures among diabetic and non-diabetic adults. JOURNAL OF DIABETES AND METABOLIC DISORDERS, v. 20, n. 2, . (14/26787-0, 15/07971-7)

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