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Physiological and genetic aspects interrelated to vitamin D in the osteosarcopenic obesity: health survey of the City of São Paulo - ISA capital

Grant number: 14/26787-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2015
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ligia Araujo Martini
Grantee:Natasha Aparecida Grande de França
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/03903-5 - Parathyroid hormone or vitamin D, which parameter is in fact associated with osteosarcopenia?, BE.EP.DR


Introduction: osteosarcopenic obesity is characterized by the simultaneous excess of adiposity, reduced muscle quantity and quality, and decreased bone mass (osteopenia or osteoporosis) and is associated with an increase in the general inflammatory state, insulin resistance, less physical exercise and consequent lower energy consumption, resulting in a vicious cycle and a deleterious synergism, with impact on the functionality and mortality of the individual. Vitamin D has well established action on bone health, but studies have pointed to extra-skeletal additional benefits since this vitamin has receptors in almost all tissues of the body, besides presenting antiinflammatory properties. Thus, vitamin D emerges as a possible key factor involved in osteosarcopenic obesity, with the hypothesis of a genetic influence. Objective: To investigate the possible physiological and genetic mechanisms interrelated to the action of vitamin D in osteosarcopenic obesity in population-based sample of adults and elderly in Sao Paulo. Methodology: adults and seniors of both sexes, participants of the Health Survey of the City of Sao Paulo (ISA- Capital 2013) (a cross-sectional study, population-based survey), randomly selected for blood collection will be included, resulting in an estimated sample of 600 individuals (300 adults and 300 elderly). The study will be divided into four steps, with the first two of ISA-Capital 2013 responsibility, and the last two will be conducted during this research project: 1) Application of questionnaires to evaluate: sex, age, skin color self-reported, sun exposure, socioeconomic status, referred weight and height, medical history and food intake (24-hours recall); 2) Application of a second 24-hour recall and blood collection; 3) Measurement of weight and height; realization of densitometry examination - DXA (bone and body composition assessment), completion of the handgrip test (grip strength) and gait speed test; 4) 51 seniors who were diagnosed with obesity, sarcopenia, sarcopenic obesity or osteosarcopenic obesity will be randomly selected to have their energy expenditure measured by doubly labeled water technique. Evaluation of serum vitamin D will be held through the collected blood analysis. Evaluation of genotyping of the vitamin D receptor gene, the protein binding of vitamin D, and the vitamin D precursor on skin will be also conducted. The distribution of the variables will be evaluated for further descriptive analysis. Correlation test will be applied between serum vitamin D and diagnostic variables. The anlysis will be conducted using the software SPSS 20.0 (SPSS Inc, Chicago IL, USA), and the significance level will be pointed as 5%. (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FRANÇA, Natasha Aparecida Grande de. Obesity associated with reduced lean mass and bone mass: an emerging and complex relationship involving biochemical, metabolic and functional changes. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública São Paulo.

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