| Grant number: | 15/20744-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | June 01, 2016 |
| End date: | May 31, 2018 |
| Field of knowledge: | Biological Sciences - Pharmacology - Clinical Pharmacology |
| Principal Investigator: | Giovana Tofoli Moniz |
| Grantee: | Giovana Tofoli Moniz |
| Host Institution: | Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated researchers: | Daniele Ribeiro de Araujo |
Abstract
In the last decades the development of drug-delivery systems, such as thermoreversible gels made it possible to manipulate some biopharmaceutical and pharmacological properties of drugs, improving their therapeutic effects (long duration of action associated to low systemic toxicity) and their clinical use. Opioids, such as tramadol, are widely used in clinical medicine for sedation or analgesia. However, these drugs can induce typical opioid side-effects, such as constipation, respiratory depression, nausea, vomiting, dependence and tolerance, even with the use of small dosages applied by different routes of administration. The use of poloxamers to form thermoreversible gels, would be interesting due to its capacity of improve the pharmacological properties of this opioid and the possibility of alterations in the posology of this drug, being potentially advantageous for the pain relief. Thus, the aim of this study is to evaluate pharmacodynamics induced by tramadol associated with poloxamers in a post-operative pain model in rats. (AU)
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