Integrated analysis of somatic mutations and transcriptional changes in noncoding regions of the pancreatic cancer genome

• Grant number: 15/50317-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2016
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Agreement: Ohio State University
• Principal Investigator: Eduardo Moraes Rego Reis
• Grantee: Eduardo Moraes Rego Reis
• Principal researcher abroad: David Symer
• Institution abroad: Ohio State University, Columbus , United States
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

The three aims in this proposal are (1) to determine novel long noncoding RNAs expressed in pancreatic cancer using RNA-seq data, (2) to detect somatic mutations in noncoding regions and to identify significantly mutated noncoding genes using WGS data from TCGA, (3) to determine cases where somatic mutations in noncoding RNA regions disrupted the expression of neighboring genes. The planned exchange activities will be instrumental to the development of the bioinformatics tools and computational analyses required to dissect the functional roles of mutations in noncoding regions in cancer genome and their part in deregulating IncRNAs aberrantly expressed in pancreatic cancer and other human tumors. (AU)