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Integrated analysis of somatic mutations and transcriptional changes in noncoding regions of the pancreatic cancer genome

Grant number: 15/50317-6
Support type:Regular Research Grants
Duration: September 01, 2016 - August 31, 2017
Field of knowledge:Biological Sciences - Biochemistry
Cooperation agreement: Ohio State University
Principal Investigator:Eduardo Moraes Rego Reis
Grantee:Eduardo Moraes Rego Reis
Principal investigator abroad: David Symer
Institution abroad: Ohio State University, Columbus, United States
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The three aims in this proposal are (1) to determine novel long noncoding RNAs expressed in pancreatic cancer using RNA-seq data, (2) to detect somatic mutations in noncoding regions and to identify significantly mutated noncoding genes using WGS data from TCGA, (3) to determine cases where somatic mutations in noncoding RNA regions disrupted the expression of neighboring genes. The planned exchange activities will be instrumental to the development of the bioinformatics tools and computational analyses required to dissect the functional roles of mutations in noncoding regions in cancer genome and their part in deregulating IncRNAs aberrantly expressed in pancreatic cancer and other human tumors. (AU)