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Using comparative genomics to understand convergent evolution of mammals: tracking the molecular footprints of the marine and riverine environment colonisation

Abstract

The availability of whole genome sequences is opening new opportunities to make progress in our understanding of the genomic bases of phenotypic diversity. It also allows non-model organisms to emerge as groups with great potential to answer questions regarding the nature of the evolutionary process. Among non-model organisms, aquatic mammals are particularly special because of the radical transformations in almost all systems during their evolutionary histories and also because of the remarkable phenotypic convergence of mammalian lineages that independently recolonized the aquatic environment. In this context, this proposal seeks to study molecular evolution of the following species: Sotalia guianensis and Pontoporia blainvillei, two marine dolphins; Sotalia fluviatilis and Inia geoffrensis, two river dolphins; and Trichechus manatus and Trichechus inunguis, a marine manatee and a riverine manatee, respectively. Using a comparative genomics approach, the whole genomes of these species will be sequenced and analyzed following two main different strategies: 1) comparison of the genomes of sister species that diverged from each other in a relatively recent time (S. guianensis x S. fluviatilis, T. manatus x T. inunguis) and in a relatively long time (I. geoffrensis x P. blainvillei); and 2) comparison of the genomes of independent lineages that occupy the same habitat (marine or riverine), to investigate whether common molecular mechanisms are responsible for convergent phenotypes. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARIANA F. NERY; MATHIAS RENNÓ; AGNELLO PICORELLI; ELISA RAMOS. A phylogenetic review of cancer resistance highlights evolutionary solutions to Peto’s Paradox. GENETICS AND MOLECULAR BIOLOGY, v. 45, n. 3, . (15/18269-1, 18/01236-1, 21/03325-4)
SILVA DE SOUZA, ERICA MARTINHA; FREITAS, LUCAS; DA SILVA RAMOS, ELISA KAREN; SELLEGHIN-VEIGA, GIOVANNA; RACHID-RIBEIRO, MICHELLE CARNEIRO; SILVA, FELIPE ANDRE; MARMONTEL, MIRIAM; DOS SANTOS, FABRICIO RODRIGUES; LAUDISOIT, ANNE; VERHEYEN, ERIK; et al. The evolutionary history of manatees told by their mitogenomes. SCIENTIFIC REPORTS, v. 11, n. 1, . (15/18269-1)
MARIZ, V, JOAO PEDRO; NERY, MARIANA F.. Unraveling the Molecular Evolution of Blood Coagulation Genes in Fishes and Cetaceans. FRONTIERS IN MARINE SCIENCE, v. 7, . (15/18269-1)
FREITAS, LUCAS; NERY, MARIANA F.. Expansions and contractions in gene families of independently-evolved blood-feeding insects. BMC Evolutionary Biology, v. 20, n. 1, . (17/25058-2, 18/19682-8, 15/18269-1)
DIAS, BRUNA C.; NERY, MARIANA F.. Analyses of RAG1 and RAG2 genes suggest different evolutionary rates in the Cetacea lineage. Molecular Immunology, v. 117, p. 131-138, . (15/18269-1, 17/14831-2)
SILVA, FELIPE ANDRE; SOUZA, ERICA M. S.; RAMOS, ELISA; FREITAS, LUCAS; NERY, MARIANA F. F.. The molecular evolution of genes previously associated with large sizes reveals possible pathways to cetacean gigantism. SCIENTIFIC REPORTS, v. 13, n. 1, p. 10-pg., . (15/18269-1, 17/25058-2, 18/01236-1)
NERY, MARIANA F.; RENNO, MATHIAS; PICORELLI, AGNELLO; RAMOS, ELISA. A phylogenetic review of cancer resistance highlights evolutionary solutions to Peto's Paradox. GENETICS AND MOLECULAR BIOLOGY, v. 45, n. 3, p. 10-pg., . (18/01236-1, 21/03325-4, 15/18269-1)
ANDREANI, MARIA LUIZA; NERY, MARIANA F.. Latitudinal diversity gradient and cetaceans from the perspective of MHC genes. IMMUNOGENETICS, v. 72, n. 6-7, . (15/18269-1)
DA SILVA RAMOS, ELISA KAREN; FREITAS, LUCAS; NERY, MARIANA F.. The role of selection in the evolution of marine turtles mitogenomes. SCIENTIFIC REPORTS, v. 10, n. 1, . (15/18269-1, 17/25058-2, 18/01236-1)
FREITAS, LUCAS; NERY, MARIANA F.. Positive selection in multiple salivary gland proteins of Anophelinae reveals potential targets for vector control. INFECTION GENETICS AND EVOLUTION, v. 100, p. 6-pg., . (18/19682-8, 17/25058-2, 15/18269-1)

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