Systemic inflammatory response evaluation in radical prostatectomy and correlation with clinical, surgical and pathological parameters

• Grant number: 16/07693-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2016
• End date: November 30, 2018
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Carlo Camargo Passerotti
• Grantee: Carlo Camargo Passerotti
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Kátia Ramos Moreira Leite ; Miguel Srougi ; Sabrina Thalita dos Reis Faria

Abstract

Prostate cancer (PCa) is the most common non-skin tumor in men and the second leading cause of death from cancer in Brazil. Among the therapeutic options for the treatment of early prostate cancer, it highlights the surgical treatment with satisfactory results, achieving results up to 94% cure in cases located. Surgical resection can be achieved by three main approaches, open surgery, laparoscopic and robotic surgery. Many studies have focused on functional and oncological outcomes compared to open surgery with robotic surgery, but here we have to evaluate the degree of induced by the two surgical techniques injury to both dosaremos serum levels of inducing hypoxia factor (HIF1±) tissue necrosis factor alpha (TNF-±) and interleukin-1² as cytokines (IL-1 ²), interleukin -6 (IL-6), interleukin 8 (IL-8) promoter inflammatory activity and IL-4 and IL-10, anti-inflammatory mediators in patients undergoing these two procedures in different surgical times, we will also dosas the creatine kinase (CK), for evaluation of muscle damage. (AU)