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HPV 16/18 vaccine: influence on the TH1/TH2 systemic and cervicovaginal immune response and on the vaginal microbiome

Grant number: 16/08392-3
Support Opportunities:Regular Research Grants
Duration: December 01, 2016 - May 31, 2019
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Paulo César Giraldo
Grantee:Paulo César Giraldo
Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers: Ana Katherine da Silveira Gonçalves de Oliveira ; Ana Paula Ferreira Costa ; Carla Taddei de Castro Neves ; José Eleutério Junior ; José Marcos Sanches Junior ; Michelle Garcia Discacciati de Carvalho


Background: The characterization of the vaginal microbiome according the local immune response profile takes an important issue nowadays, when many women will receiving the HPV vaccine, which induces na specific immune microenvironment. However, the local and systemic immune effects in vaccinated women and the possible influences on the vaginal microbiome are not completely understood. Objective: Characterize the cervicovaginal and systemic immune response by measuring of TH1/TH2 levels and correlate with vaginal microbiome, before and after vaccination by bivalent HPV 16/18 vaccine (Cervarix®). Methods: Twenty women will be included in this study and will receive the bivalent HPV 16/18 vaccine (Cervarix®). The level of TH1(INF-³, IL2, IL-12, TNF-±) and TH2 (IL-4, IL-5, IL-10, IL-13) cytokines will be measured the in serum and cervicovaginal samples, by ELISA multiplex. The analysis of the vaginal microbiome will be made by Nugent criteria and bacterial pyrosequencing ribosomal 16S RNA gene. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIRALDO, PAULO CESAR; SANCHES, JOSE MARCOS; SPARVOLLI, LUIZ GUSTAVO; AMARAL, ROSE; MIGLIORINI, ISABEL; GIL, CRISTIANE DAMAS; TADDEI, CARLA ROMANO; WITKIN, STEVEN S.; DISCACCIATI, MICHELLE GARCIA. Relationship between Papillomavirus vaccine, vaginal microbiome, and local cytokine response: an exploratory research. Brazilian Journal of Microbiology, v. 52, n. 4, . (16/08392-3)

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