Predicting survival in non-small-cell lung cancer: a link between cancer cachexia, cardiorespiratory fitness and cancer immune surveillance?

• Grant number: 16/50336-3
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2016
• End date: November 30, 2019
• Field of knowledge: Health Sciences - Physical Education
• Agreement: University of Bath
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Patricia Chakur Brum
• Grantee: Patricia Chakur Brum
• Principal researcher abroad: James Turnet
• Institution abroad: University of Bath , England
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated research grant: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment, AP.TEM

Abstract

The present work will translate these findings into patients diagnosed with NSCLC. Our aims are to (A) establish the mechanistic role of our biomarkers in cachexia progression (B) to establish the contributing effects of cachexia and cardiorespiratory fitness on NSCLC prognosis and (C) to examine likely immunological mechanisms that explain why cachexia and low cardiorespiratory fitness are linked to poor clinical outcomes and shorter survival. NSCLC patients (n=20-30, 50% male) will be recruited at the time of diagnosis. Prior to treatment, and following five months of chemotherapy, we will undertake a number of procedures including, but not limited to, collecting a vastus laterals muscle biopsy to investigate mechanisms of cachexia, collecting a blood sample for analysis of inflammatory and immunological variables, and directly measuring cardiorespiratory fitness and muscle function. Aims (B) and (C) are only possible due to the combined expertise of Dr Turner (University of Bath, UK) and Dr Brum (USP, Brazil). Award of this FAPESP/SPRINT application will cement an exciting multidisciplinary international collaboration, allowing mobility of principle investigators, research staff and collaborators, between Bath and USP for data collection, laboratory analysis, undergraduate teaching, and research seminars. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, CHRISTIANO R. R.; NEVES, WILLIAN DAS; ALMEIDA, NEY R. DE; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/ TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, SEP 2020. (16/50336-3, 12/02528-0, 14/03016-8, 12/25240-1, 15/22814-5, 16/01478-0, 16/20187-6)

ALVES, CHRISTIANO R. R.; EICHELBERGER, ERIC J.; DAS NEVES, WILLIAN; RIBEIRO, MARCIO A. C.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; DE ALMEIDA, NEY R.; HAGEN, LARS; SHARMA, ANIMESH; FERREIRA, JULIO C. B.; et al. Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. FASEB JOURNAL, v. 35, n. 7, JUL 2021. (16/50336-3, 16/01478-0, 12/25240-1, 16/20187-6, 15/22814-5, 14/03016-8, 12/02528-0)

ALVES, CHRISTIANO R. R.; DAS NEVES, WILLIAN; DE ALMEIDA, NEY R.; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, p. 17-pg., 2020-09-01. (16/50336-3, 14/03016-8, 16/20187-6, 12/25240-1, 16/01478-0, 15/22814-5, 12/02528-0)

RIANI COSTA, LUIZ AUGUSTO; BARRETO, RAPHAEL F.; DE LEANDRINI, SARAH MILANI MORAES; GURGEL, ALINE RACHEL BEZERRA; DE SALES, GABRIEL TOLEDO; VOLTARELLI, VANESSA AZEVEDO; DE CASTRO, JR., GILBERTO; FENTON, SALLY A. M.; TURNER, JAMES E.; KLAUSENER, CHRISTIAN; et al. The influence of a supervised group exercise intervention combined with active lifestyle recommendations on breast cancer survivors' health, physical functioning, and quality of life indices: study protocol for a randomized and controlled trial. Trials, v. 22, n. 1, DEC 18 2021. (15/22814-5, 20/12514-2, 17/13133-0, 16/50336-3)

DIEGO SALES DE OLIVEIRA; LUCAS SERTORIO CARRASCOZA; NEY ROBSON DE ALMEIDA; LEANDRO CAMPOS DE BRITO; MARCELO MARQUES; LEANDRO SILVA ALVES; PATRICIA CHAKUR BRUM. Cardiovascular physiology and autonomic heart control principles: the use of a station rotation strategy to recall basic cardiovascular knowledge among exercise science students. Motriz: rev. educ. fis., v. 28, 2022-03-28. (16/19771-5, 15/22814-5, 16/50336-3)