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Face to Aedes aegypti: action of ammonium Quaternary as potential insecticide activity

Grant number: 16/15245-7
Support type:Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Biological Sciences - Parasitology - Entomology and Malacology of Parasites and Vectors
Cooperation agreement: CNPq - PPSUS
Principal Investigator:Margarete Teresa Gottardo de Almeida
Grantee:Margarete Teresa Gottardo de Almeida
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Assoc. researchers: Marluci Monteiro Guirado


Aedes aegypti, a cosmopolitan mosquito, has a biological robustness and adaptive capacity to remain in urban environments, with highly competent vector capability to spread several arboviruses. A number of chemicals have been used for insect control, but their effectiveness is low given the high population density and vector resistance. The search for alternative forms of control has been encouraged by researchers from several educational institutions, as well as by government programs. Thus, a novel compound derived from coconut oil, quaternary ammonium, which is effective in the control of microorganisms, is of great interest because of its low toxicity, water solubility, high stability, and biodegradability with low environmental impact. This project was designed to evaluate the insecticidal activity of a potentiated quaternary ammonium on all mosquito development stages. This study will use strains of A. aegypti from São José do Rio Preto. After collection, eggs of A. aegypti will be taken to the insectarium of the SUCEN-FAMERP Vector Laboratory (Superintendência de controle de endemias, Medicine School in Sao Jose do Rio Preto) to develop bioassays. Further studies on the environmental impact of quaternary ammonium will be conducted in the UNESP Environmental Chemistry Laboratory using fish, as this lab is specialized in this area. To look for more effective alternative products, presenting fast action, safe for environment, of the low cost, it is necessary, thus, the compound derived from coconut oil, QA potentiated, will be used to face the A. aegypti. (AU)