| Grant number: | 16/18155-9 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2017 |
| End date: | July 31, 2019 |
| Field of knowledge: | Biological Sciences - Immunology - Applied Immunology |
| Principal Investigator: | Maria Terezinha Serrão Peraçoli |
| Grantee: | Maria Terezinha Serrão Peraçoli |
| Host Institution: | Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| City of the host institution: | Botucatu |
| Associated researchers: | Jose Carlos Peraçoli ; Mariana Leticia Matias ; Mariana Romão Veiga ; Priscila Rezeck Nunes ; Vanessa Rocha Ribeiro Vasques ; Vera Therezinha Medeiros Borges |
Abstract
The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory cytokines, associated with reduction of regulatory cytokines and abnormally activated phenotype of cells of innate and adaptive immunity. Thus, both in the systemic circulation and in placenta occur an imbalance between pro-and anti-inflammatory cytokines, activation of NLRP1 and NLRP3 inflammasomes and a polarization of monocytes and T lymphocytes subpopulations to an inflammatory profile, probably dependent on regulatory factors deficiency capable of modulating this inflammatory response. This imbalance could be reduced by the treatment with substances derived from natural products with anti-inflammatory activity, vitamin D and hormones such as progesterone. The present project consisting of four sub-projects has been developed with the objective of evaluating the mechanisms involved in placental and systemic inflammatory responses detected in pregnant women with PE, and to investigate the immunomodulatory effect of hormones such as progesterone, natural products with anti-inflammatory activity such as silybin and vitamin D on monocytes, T cell subsets and placental tissue obtained from preeclamptic women. Thus, the vitro treatment of placental explants and T lymphocytes with vitamin D, and the study of cell signaling pathways in monocytes will allow better understanding of the processes involved in systemic inflammation of PE, and possibly propose alternative ways to treat this important pregnancy syndrome. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |