Nutritional status and frailty as predictors of infectious and non-infectious complications in kidney transplant recipients

• Grant number: 16/24745-3
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2017
• End date: April 30, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ricardo Augusto Monteiro de Barros Almeida
• Grantee: Ricardo Augusto Monteiro de Barros Almeida
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Luís Gustavo Modelli de Andrade ; Ricardo de Souza Cavalcante ; Sebastião Pires Ferreira Filho ; Sílvia Justina Papini

Abstract

Currently, kidney transplantation (KTx) is the best therapeutic alternative for patients with end-stage renal disease (ESRD). Some criteria are used to provide a more accurate indication for KTx, which include medical, surgical and psychosocial evaluations of the patient, as well as verification of donor-recipient compatibility. All these evaluations are performed with the purpose of minimizing possible post-KTx complications. Nutritional assessment is of fundamental importance and should receive more attention in the pre- and post-KTx period, since the nutritional status of the patient may interfere in the transplantation outcomes. Recently, fragility has been used as a possible predictor of KTx outcomes. It is a physiological reserve measure that has been related to the occurrence of delayed graft function, early hospital readmission and mortality. The association between nutritional status prior to KTx and frailty as possible predictors of infectious and noninfectious post-transplant outcomes appears to be unprecedented in the literature. The aim of the present study will be to evaluate the fragility and nutritional status of the patients as predictors of infectious and noninfectious outcomes after kidney transplantation. It will be developed at the Kidney Transplant Service of the Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP (HC-FMB). The sample should be composed of patients older than 18 years, submitted to KTx between March 2017 and March 2018. Frailty will be based on five components: shrinking; weakness; exhaustion (self-report); low activity; and slowed walking speed. The nutritional status will be assessed through body composition, segmental bioimpedance, and anthropometric data. Data will be collected in two moments, just before and three months after the KTx. The collection of information on demographics, personal history and kidney transplantation will be performed through the electronic medical record. Fragility and body composition will be related to infectious and non-infectious outcomes in the post-KTx period. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MANTOVANI, MILENA DOS SANTOS; DE CARVALHO, NYARA COELHO; ARCHANGELO, THOMAZ EDUARDO; MODELLI DE ANDRADE, LUIS GUSTAVO; FERREIRA FILHO, SEBASTIAO PIRES; CAVALCANTE, RICARDO DE SOUZA; KAWANO, PAULO ROBERTO; PAPINI, SILVIA JUSTINA; COSTA, NARA ALINE; MONTEIRO DE BARROS ALMEIDA, RICARDO AUGUSTO. Frailty predicts surgical complications after kidney transplantation. A propensity score matched study. PLoS One, v. 15, n. 2, FEB 26 2020. (16/24745-3)

MANTOVANI, MILENA DOS SANTOS; DE CARVALHO, NYARA COELHO; MINICUCCI, MARCOS FERREIRA; MODELLI DE ANDRADE, LUIS GUSTAVO; CAVALCANTE, RICARDO DE SOUZA; DE ALMEIDA, GABRIEL BERG; COSTA, NARA ALINE; DA SILVA, JULHIANY DE FATIMA; DE BARROS ALMEIDA, RICARDO AUGUSTO MONTEIRO. Transitions in frailty state 12 months after kidney transplantation: a prospective cohort study. JOURNAL OF NEPHROLOGY, v. 35, n. 9, p. 9-pg., 2022-09-01. (16/24745-3)