| Grant number: | 16/22488-3 |
| Support Opportunities: | Regular Research Grants |
| Start date: | May 01, 2017 |
| End date: | April 30, 2019 |
| Field of knowledge: | Biological Sciences - Parasitology - Helminthology of Parasites |
| Principal Investigator: | Josué de Moraes |
| Grantee: | Josué de Moraes |
| Host Institution: | Universidade Universus Veritas Guarulhos (Univeritas UNG). Guarulhos , SP, Brazil |
| Associated researchers: | Ademar Alves da Silva Filho ; Ana Carolina Mafud ; Damião Pergentino de Sousa ; José Roberto de Souza de Almeida Leite ; Marta Ferreira Bastos ; Yvonne Primerano Mascarenhas |
Abstract
The diseases caused by helminth parasites occur mainly in the poorest social strata, without adequate housing, work, education, health services. Also known as "diseases of poverty", these diseases affect more than 1 billion people worldwide and are responsible for millions of deaths annually. Unfortunately, treatment options are insufficient, whose screenplay is exacerbated by disregard of the pharmaceutical industry in developing new drugs for low-income population. Considered a neglected disease, schistosomiasis is considered an important public health problem in more than 70 countries. It is estimated that there, worldwide, more than 200 million individuals infected and 800 million people are at risk. Currently, treatment of schistosomiasis is based on the use of only one drug, praziquantel, but extensive and inappropriate use culminated in the emergence of resistance. Additionally, praziquantel is the most widely drugs used for the treatment and control of parasites in domestic and farm animals. In this sense, the main activities are research and technological development for the control of schistosomiasis and other helminthiasis. The search for new therapies, drug repositioning has been a promising strategy with the use of drugs already available and approved for clinical use in other diseases. This project aims to study new therapies with the use of drugs (repositioning) using Schistosoma mansoni worm (BH strain) as experimental model. Using bioassays, we aim to obtain novel drugs with ex vivo and in vivo anthelmintic properties. Moreover, this project aims to contribute to the training of human resources. (AU)
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