Development of voltammetric sensors for determination of cocaine and delta-9-tetrahydrocannabinol in samples seized by the police

• Grant number: 16/23825-3
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2017
• End date: May 31, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Marcelo Firmino de Oliveira
• Grantee: Marcelo Firmino de Oliveira
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This project aims to develop alternative voltammetric methodologies for the analysis of trace elements of cocaine and D-9-THC (the most potent active principle of marijuana) through printed electrodes, for use in forensic laboratories and crime scenes. The aforementioned substances should be inserted on the electrode surfaces of printed electrodes and the electrochemical behavior of the analytes in question on the surface of these electrodes should be investigated. Standard solutions of the analytes of interest, previously deoxygenated and enriched with electrolyte-carrier, will be added to the surface of the printed electrodes.For the studies of electrochemical behavior, the voltammetric modalities of cyclic sweep, as well as differential pulse and square wave will be used, and the amperometric responses of each analyte, as well as its oxidation and / or reduction potentials should be investigated. Once the optimized conditions of electrochemical response have been defined, as well as the validation tests of the technique, it is intended to perform the determination step of these analytes in samples seized forensic interest, through a partnership already established with the local post of the Institute of Criminalistics.It should be noted that, in the real sample dosing step, the comparison study will be carried out with a conventional technique of previously established methodology, and a portable Raman spectrophotometer, which is requested in this project, should be used.In relation to the disposable printed platforms, the group has commercial electrodes from BVT and Palmsens, as well as currently also develops platforms on microfluidic paper, with impressions made with conductive material. However, in order to carry out the proposed experiments, it becomes crucial to acquire the equipment requested in said application, which is a miniaturized Raman spectrophotometer, with the possibility of transporting the same and subsequent field analysis. (AU)

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OIYE, ERICA NAOMI; TOIA KATAYAMA, JULIANA MIDORI; MUZETTI RIBEIRO, MARIA FERNANDA; DE OLIVEIRA, MARCELO FIRMINO. Electrochemical analysis of 25H-NBOMe by Square Wave Voltammetry. FORENSIC CHEMISTRY, v. 5, p. 86-90, SEP 2017. (16/23825-3)

MURILO ALVES, GUSTAVO; SOARES CASTRO, ALEX; MCCORD, BRUCE ROYSTON; DE OLIVEIRA, MARCELO FIRMINO. MDMA Electrochemical Determination and Behavior at Carbon Screen-printed Electrodes: Cheap Tools for Forensic Applications. Electroanalysis, v. 33, n. 3, NOV 2020. (19/04439-3, 19/19796-6, 16/23825-3)

ELEOTERIO, IZABEL C.; BALBINO, MARCO A.; DE ANDRADE, JOSE F.; FERREIRA, BRUNO; SACZK, ADELIR A.; OKUMURA, LEONARDO L.; BATISTA, ANTONIO CARLOS F.; DE OLIVEIRA, MARCELO F.. Analysis of sulfamethoxazole by square wave voltammetry using new carbon paste electrode. JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING, v. 8, n. 4, p. 281-289, 2018. (16/23825-3, 11/10216-5)

DEFENDI DA SILVA, ANA BEATRIZ; CASTRO, ALEX SOARES; DE OLIVEIRA, MARCELO FIRMINO. Development of Carbon Paste Electrode Chemically Modified with Schiff Base Complexes for Forensic Analysis of Cocaine. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 9, n. 34, p. 12-pg., 2022-01-01. (16/23825-3)

DUARTE, LEANDRO OKA; FERREIRA, BRUNO; SILVA, GABRIELA R.; IPOLITO, ANTONIO J.; DE OLIVEIRA, MARCELO F.. Validated green phenyl reversed-phase LC method using ethanol to determine MDMA in seized ecstasy tablets. Journal of Liquid Chromatography & Related Technologies, v. 43, n. 17-18, SEP 2020. (16/23825-3)

RIBEIRO, MARIA FERNANDA M.; BENTO, FATIMA; IPOLITO, ANTONIO J.; DE OLIVEIRA, MARCELO F.. Development of a Pencil Drawn Paper-based Analytical Device to Detect Lysergic Acid Diethylamide (LSD). JOURNAL OF FORENSIC SCIENCES, v. 65, n. 6, JUN 2020. (16/23825-3)

LIMA, GUILHERME VIEIRA; MELLO, LUCAS DOS SANTOS; DOCKAL, EDWARD RALPH; DE OLIVEIRA, MARCELO FIRMINO. Electrochemical determination of ethanol on carbon paste electrode chemically modified with [N,N '-cis-1,2-cyclohexylene bis (salicylideneaminate)] nickel(II) Schiff base complex. Microchemical Journal, v. 175, p. 10-pg., 2022-01-21. (16/23825-3)

CASTRO, ALEX SOARES; DE AZEVEDO, LARISSA SILVA; BRUNI, ALINE THAIS; TELES DE MENEZES, MATHEUS MANOEL; DOCKAL, EDWARD RALPH; DE OLIVEIRA, OSMAIR VITAL; FERREIRA, BRUNO; DE OLIVEIRA, MARCELO FIRMINO. Cocaine electrooxidation behavior, mechanism, and kinetics on a carbon paste electrode chemically modified with a cobalt or copper Schiff base complex. FORENSIC CHEMISTRY, v. 26, DEC 2021. (16/23825-3, 16/01447-7)

OIYE, ERICA NAOMI; KATAYAMA, JULIANA MIDORI TOIA; RIBEIRO, MARIA FERNANDA MUZETTI; DUARTE, LEANDRO OKA; BAKER BOTELHO, RODRIGO DE CASTRO; IPOLITO, ANTONIO JOSE; MCCORD, BRUCE ROYSTON; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric detection of 3,4-methylenedioxymethamphetamine (mdma) in saliva in low cost systems. FORENSIC CHEMISTRY, v. 20, p. 8-pg., 2020-08-01. (16/23825-3)

FERREIRA, BRUNO; DUARTE, LEANDRO OKA; OIYE, ERICA NAOMI; MUZETTI RIBEIRO, MARIA FERNANDA; TOIA KATAYAMA, JULIANA MIDORI; BARROS OLIVA, PEDRO HENRIQUE; DE OLIVEIRA, MARCELO FIRMINO. A simple and fast method to detect freebase cocaine in artificial saliva by square wave voltammetry (SWV) using carbon paste electrode. JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING, v. 10, n. 4, p. 11-pg., 2020-01-01. (16/23825-3)

CASTRO, ALEX SOARES; TELES DE MENEZES, MATHEUS MANOEL; ALVES, GUSTAVO MURILO; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric analysis of cocaine hydrochloride at carbon paste electrode chemically modified with N,N `-ethylene-bis-(salicylideneiminato) manganese(II) Schiff base complex. Microchemical Journal, v. 153, MAR 2020. (16/23825-3, 16/01447-7)

CASTRO, ALEX SOARES; PINKE RODRIGUES, CAIO HENRIQUE; TELES DE MENEZES, MATHEUS MANOEL; DEFENDI DA SILVA, ANA BEATRIZ; BRUNI, ALINE THAIS; DE OLIVEIRA, MARCELO FIRMINO. Fe(II), Ni(II), Cu(II), and Co(II) salen Schiff base complexes: Proposal for a voltammetric sensor to analyze cocaine hydrochloride and its interferents. FORENSIC CHEMISTRY, v. 25, AUG 2021. (16/01447-7, 16/23825-3)

CASTRO, ALEX SOARES; TELES DE MENEZES, MATHEUS MANOEL; ALVES, GUSTAVO MURILO; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric analysis of cocaine hydrochloride at carbon paste electrode chemically modified with N,N '-ethylene-bis-(salicylideneiminato) manganese(II) Schiff base complex. Microchemical Journal, v. 153, p. 7-pg., 2020-03-01. (16/23825-3, 16/01447-7)

CASTRO, ALEX SOARES; DE AZEVEDO, LARISSA SILVA; PINKE RODRIGUES, CAIO HENRIQUE; CALEFFI PATELLI, ANA CAROLINA; BRUNI, ALINE THAIS; DE OLIVEIRA, MARCELO FIRMINO. Use of voltammetric and chemometric tools to develop a sensor in forensic chemistry. TALANTA OPEN, v. 5, p. 12-pg., 2022-08-01. (16/23825-3, 16/01447-7)