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Fentanyl analysis at carbon paste electrodes modified with Schiff base complexes and screen-printed electrodes coupled to characterization of seized amphetamine samples employing SERS: contributions to public healthcare policies

Grant number: 19/19796-6
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): January 15, 2020
Effective date (End): May 14, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Marcelo Firmino de Oliveira
Grantee:Gustavo Murilo Alves
Supervisor: Bruce Royston McCord
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Florida International University (FIU), United States  
Associated to the scholarship:19/04439-3 - Study of the redox process of the molecules of MDMA, MDA and MDEA on surface of a chemically modify electrode with Schiff Bases: development of a voltammetric sensor for forensic interest, BP.IC


Indirect fentanyl consumption by ingestion of MDMA samples has been causing deaths due to overdose. This research project aims to apply modified sensors and screen-printed electrodes to detect fentanyl. The use of Surface Enhanced Raman Spectroscopy (SERS) will make the project even more robust. The ultimate goal is to construct an electrode that can be employed as a commercial sensor, thereby contributing to healthcare policies. Familiarization with the SERS technique will be possible through the visit to the laboratory that has pioneered its application in forensic samples. SERS analyses will be carried out by using metallic nanoparticles to amplify the fentanyl Raman signal in samples that mimic seized MDMA matrixes. Data will be recorded in a Raman spectrometer equipped with an excitation laser. Electrochemical analyses will be performed in a potentiotast linked to a computer. The electrode cell arrangement will include an Ag/AgCl reference electrode, a platinum wire as counter electrode, and a commercial screen-printed electrode or a carbon paste electrode modified with a Schiff base complex (prepared during the research project associated with the present scholarship application) as working electrode. First, cyclic voltammetry will be conducted for both electrodes. Then, their capacity to quantify fentanyl will be verified by means of more sensitive techniques. Next, qualitative data (from SERS experiments) and quantitative data (from electrochemistry assays) will be compared. Building a method that can analyze a well-known profile of seized MDMA samples will contribute to public healthcare policies. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MURILO ALVES, GUSTAVO; SOARES CASTRO, ALEX; MCCORD, BRUCE ROYSTON; DE OLIVEIRA, MARCELO FIRMINO. MDMA Electrochemical Determination and Behavior at Carbon Screen-printed Electrodes: Cheap Tools for Forensic Applications. Electroanalysis, v. 33, n. 3, . (19/04439-3, 19/19796-6, 16/23825-3)

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