Development of electroanalytical methods for detection/discrimination of drugs of abuse, its adulterants and explosives in forensic samples

• Grant number: 11/19903-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: February 01, 2012
• End date: March 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Thiago Regis Longo Cesar da Paixão
• Grantee: William Reis de Araujo
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 14/00788-0 - Development of electrochemical sensors for detection and discrimination of forensic samples, BE.EP.DD

Abstract

Electrochemical techniques have been received increasing attention in the forensic field and for monitoring different chemical species. Hence, this research project focused on developing analytical methods for the quantification/discrimination of abuse drugs in biological fluids, specifically in urine using chemically modified electrodes and techniques of paper chromatography with electrochemical detection. The process of discrimination is performed using voltammetric electronic tongues, that is, a set of non-specific voltammetric sensors with low selectivity but high sensitivity associated with unsupervised pattern recognition methods to process the information for the discrimination. The development of these devices can result in greater flexibility in the process of discrimination of the doping process. Nowadays, this control requires several preparation steps and requiring large time between the analysis sample and the solution of the case. Additionally, these techniques require well-trained and expensive equipment. For this reason, it is interesting to develop new rapid analytical methods, which provide accurate and analysis "in situ" of these biological matrices, such as urine. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JUNQUEIRA, JOAO R. C.; DE ARAUJO, WILLIAM R.; SALLES, MAIARA O.; PAIXAO, THIAGO R. L. C.. Flow injection analysis of picric acid explosive using a copper electrode as electrochemical detector. Talanta, v. 104, p. 162-168, JAN 30 2013. (11/11115-8, 12/12106-5, 11/19903-5)

DA SILVA, GABRIELA O.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Portable and low-cost colorimetric office paper-based device for phenacetin detection in seized cocaine samples. Talanta, v. 176, p. 674-678, JAN 1 2018. (17/10522-5, 11/19903-5, 16/16477-9)

SALLES, MAIARA O.; ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen. Journal of the Brazilian Chemical Society, v. 27, n. 1, p. 54-61, JAN 2016. (12/12106-5, 11/11115-8, 11/19903-5)

SALLES, M. O.; MELONI, G. N.; DE ARAUJO, W. R.; PAIXAO, T. R. L. C.. Explosive colorimetric discrimination using a smartphone, paper device and chemometrical approach. ANALYTICAL METHODS, v. 6, n. 7, p. 2047-2052, 2014. (11/11115-8, 12/12106-5, 11/19903-5)

GUIMARAES SELVA, THIAGO MATHEUS; DE ARAUJO, WILLIAM REIS; LONGO CESAR DA PAIXAO, THIAGO REGIS. Non-Invasive Salivary Electrochemical Quantification of Paraquat Poisoning Using Boron Doped Diamond Electrode. Electroanalysis, v. 27, n. 7, p. 1642-1648, JUL 2015. (12/12106-5, 11/19903-5)

DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R.L.C.. Use of copper electrode for melamine quantification in milk. Electrochimica Acta, v. 117, p. 379-384, JAN 20 2014. (11/19903-5)

BUENO, LIGIA; DE ARAUJO, WILLIAM R.; SALLES, MAIARA O.; KUSSUDA, MARCOS Y.; PAIXAO, THIAGO R. L. C.. Voltammetric Electronic Tongue for Discrimination of Milk Adulterated with Urea, Formaldehyde and Melamine. CHEMOSENSORS, v. 2, n. 4, p. 16-pg., 2014-12-01. (12/12106-5, 11/23355-3, 11/11115-8, 11/19903-5)

SILVA, THALITA G.; DE ARAUJO, WILLIAM R.; MUNOZ, RODRIGO A. A.; RICHTER, EDUARDO M.; SANTANA, MARIO H. P.; COLTRO, WENDELL K. T.; PAIXAO, THIAGO R. L. C.. Simple and Sensitive Paper-Based Device Coupling Electrochemical Sample Pretreatment and Colorimetric Detection. Analytical Chemistry, v. 88, n. 10, p. 5145-5151, MAY 17 2016. (11/19903-5)

DE ARAUJO, W. R.; PAIXAO, T. R. L. C.. Fabrication of disposable electrochemical devices using silver ink and office paper. ANALYST, v. 139, n. 11, p. 2742-2747, 2014. (12/12106-5, 11/19903-5)

DE ARAUJO, WILLIAM R.; MALDANER, ADRIANO O.; COSTA, JOSE L.; PAIXAO, THIAGO R. L. C.. Development of an electroanalytical method for the quantification of aminopyrine in seized cocaine samples. Microchemical Journal, v. 121, p. 213-218, JUL 2015. (12/12106-5, 11/19903-5)

DE ARAUJO, WILLIAM R.; SALLES, MAIARA O.; PAIXAO, THIAGO R. L. C.. Development of an enzymeless electroanalytical method for the indirect detection of creatinine in urine samples. SENSORS AND ACTUATORS B-CHEMICAL, v. 173, p. 847-851, OCT 2012. (11/11115-8, 09/07859-1, 11/19903-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ARAUJO, William Reis de. Development of electrochemical and colorimetric sensors for application in forensic interest samples. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.