Temporal Dynamics of Memory Modulation by Corticosterone

• Grant number: 17/03820-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: April 30, 2020
• Field of knowledge: Humanities - Psychology - Physiological Psychology
• Principal Investigator: Raquel Vecchio Fornari
• Grantee: Raquel Vecchio Fornari
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• City of the host institution: Santo André
• Associated researchers: Paula Ayako Tiba ; Tatiana Lima Ferreira
• Associated scholarship(s): 19/12763-5 - Mapping of encephalic regions involved in the retrieval of contextual memory in animals trained with different shock intensities, BP.TT; 18/18346-4 - Mapping of encephalic regions involved in the retrieval of contextual memory in animals trained with different shock intensities, BP.TT

Abstract

Several studies have shown that glucocorticoids (cortisol in humans and corticosterone - CORT - in rats), released during emotional or stressful situations, improve memory. The CORT hormone acts in different brain regions, including the hippocampus, to increase the consolidation of various types of memory tasks, such as the contextual fear conditioning (CFC). Some evidence indicates that the hippocampus has a limited temporal role in the processing of memories, which, over time, become stabilized and stored in the neocortex, with a consequent reduction in their specificity. Despite emotional memories being always referred to as well remembered for long periods of time, there are no studies that have investigated the temporal dynamics of CORT induced modulation of memory specificity and duration. This project will investigate the role of plasmatic CORT, released after different CFC training intensities, on the specificity and duration of contextual memory in rats. The possible involvement of different brain regions, such as the hippocampus, amygdala and cerebral cortex, in the retrieval of recent and remote CFC memory, induced by different training intensities, will also be examined. Moreover, the involvement of glucocorticoid receptors, immediately after training, in the specificity and duration of contextual memory will be analyzed. The results will, therefore, help to increase our knowledge about the behavioral, biochemical and neuroanatomical mechanisms involved in the effects of emotion and/or alert, on the formation and maintenance of long-term memory. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

CORREA, MOISES DOS SANTOS; VAZ, BARBARA DOS SANTOS; VIEIRA GRISANTI, GABRIEL DAVID; QUEIROZ DE PAIVA, JOSELISA PERES; TIBA, PAULA AYAKO; FORNARI, RAQUEL VECCHIO. Relationship between footshock intensity, post-training corticosterone release and contextual fear memory specificity over time. PSYCHONEUROENDOCRINOLOGY, v. 110, DEC 2019. (11/10062-8, 15/26983-6, 17/03820-0)

DOS SANTOS CORREA, MOISES; GRISANTI, GABRIEL DAVID VIEIRA; FRANCISCATTO, ISABELLE ANJOS FERNANDES; TARUMOTO, TATIANA SUEMI ANGLAS; TIBA, PAULA AYAKO; FERREIRA, TATIANA LIMA; FORNARI, RAQUEL VECCHIO. Remote contextual fear retrieval engages activity from salience network regions in rats. NEUROBIOLOGY OF STRESS, v. 18, p. 11-pg., 2022-05-01. (17/03820-0)

CORREA, MOISES DOS SANTOS; VAZ, BARBARA DOS SANTOS; MENEZES, BEATRIZ SCAZUFCA; FERREIRA, TATIANA LIMA; TIBA, PAULA AYAKO; FORNARI, RAQUEL VECCHIO. Corticosterone differentially modulates time-dependent fear generalization following mild or moderate fear conditioning training in rats. NEUROBIOLOGY OF LEARNING AND MEMORY, v. 184, p. 10-pg., 2021-10-01. (17/03820-0, 17/24012-9)