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Functional biomarkers of the immune response in human tuberculosis

Grant number: 17/05365-8
Support type:Regular Research Grants
Duration: August 01, 2017 - July 31, 2019
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Fabiani Gai Frantz
Grantee:Fabiani Gai Frantz
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Tuberculosis (TB) is a bacterial infectious disease caused by Mycobacterium tuberculosis, still considered a serious public health problem. It is estimated that one-third of the world's population is infected with M. tuberculosis, with the latent form of the disease which can be reactivated. Moreover, the lack of rapid and sensitive diagnostic, inadequate adherence to treatment and the acquisition of resistance to antibiotics by bacteria, further jeopardize this frame. With this project, new molecular targets aiming diagnosis and therapy will be explored. To explore the signaling pathways of the Notch receptor and its ligands will be a challenge of our project. This pathway is described as important in maintaining the immune response and can influence the dynamics of the immunity against bacilli. Another challenge will be understand how hypomethylation of cells from innate immunity could modulate the host response to infection. Currently, the use of drugs that act by modifying the DNA methylation pattern, the "epidrugs", have been explored as modulators of the immune response in tumors. Exploring the effect of these drugs during infections, considering their possibilities of clinical use is relevant in this scenario. Therefore, we wonder to investigate those two gaps in the literature, revealing immune response pathways that can be correlated with clinical data, and thereafter, new diagnostic and treatment biomarkers could be explored in this pathology. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESPINDOLA, MILENA S.; SOARES, LUANA S.; GALVAO-LIMA, LEONARDO J.; ZAMBUZI, FABIANA A.; CACEMIRO, MAIRA C.; BRAUER, VERONICA S.; MARZOCCHI-MACHADO, CLENI M.; GOMES, MATHEUS DE SOUZA; AMARAL, LAURENCE R.; MARTINS-FILHO, OLINDO A.; BOLLELA, VALDES R.; FRANTZ, FABIANI G. Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection. SCIENTIFIC REPORTS, v. 8, APR 3 2018. Web of Science Citations: 5.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.