Involvement of NFKB kinase inducer on liver regeneration in mice submitted to partial hepatectomy.

• Grant number: 16/18321-6
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2017
• End date: June 30, 2019
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Adriana Souza Torsoni
• Grantee: Adriana Souza Torsoni
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated researchers: Marciane Milanski Ferreira ; Marcio Alberto Torsoni

Abstract

In recent decades, obesity and metabolic syndrome have become increasingly prevalent in the world population. Exposure to lipid overload is capable of inducing not only the development of obesity and its complications, such as hepatic steatosis, but also program the individual and its descendants, by epigenetic modifications, to important metabolic changes for several generations. Among the epigenetic mechanisms, microRNAs modulation has gained prominence for its direct action in target genes through post-transcriptional regulation. Consumption of high-fat diet can induce changes in hepatic lipogenesis, oxidative mitochondrial damage and inflammatory processes mediated by changes in the expression of microRNAs, which could increase the predisposition to change as NAFLD, disease characterized by TAG accumulation in hepatocytes, and it takes more than 20% of affected with some type of surgical liver resection. Recent literature suggests that liver fat accumulation can be a detrimental factor in the regenerative process, although the mechanisms involved in this process are not yet well defined. It has been hypothesized that the overactivation of key elements of inflammatory pathways, such as NFkB pathway, can be one of the factors that trigger the failure in the regenerative process, dependent of inflammation. Thus, the objective of this project is to investigate whether obese mice showed worse liver regeneration following surgical resection procedure, resulting from changes in the functioning of non-canonical inflammatory pathway of NFkB and its relationship with the expression of microRNAs involved in the modulation of inflammation, tissue repair and cell cycle. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PANZARIN, CAROLINA; DE PAULA SIMINO, LAIS ANGELICA; SILVA MANCINI, MARIANA CAMARGO; IGNACIO-SOUZA, LETICIA MARTINS; MILANSKI, MARCIANE; TORSONI, MARCIO ALBERTO; TORSONI, ADRIANA SOUZA. Hepatic microRNA modulation might be an early event to non-alcoholic fatty liver disease development driven by high-fat diet in male mice. MOLECULAR BIOLOGY REPORTS, v. 49, n. 4, p. 12-pg., 2022-01-20. (16/18321-6)