Evaluation of anti-inflammatory potential of indomethacin incorpored to mesoporose silica nanoparticle

• Grant number: 17/10241-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2017
• End date: October 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Ricardo Andrade Furtado
• Grantee: Ricardo Andrade Furtado
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Indomethacin is considered a potent anti-inflammatory, but its undesirable side effects such as ulcerations and even bleeding leading to discontinuation of drug treatment. One of the ways to reduce undesirable effects is the association of drugs with nanoparticles, which has been used with great frequency in recent times, promoting a high quality in the distribution of compounds in their specific sites of action and consequently reducing the therapeutic dose. Mesoporous silica structures are being studied by the ability of bioconjugation with different molecules, to be distinguished by the fact that it has the ability to penetrate the cell membrane and by the high efficiency in the incorporation of several therapeutic agents, which can be released in a controlled manner at the sites target. In this sense, the present work aims to evaluate the anti-inflammatory potential of indomethacin incorporated into nanoparticles of mesoporous silica. To do so, the nociceptive potential will be evaluated by different tests such as formalin, paw edema, inflammatory mediator dosage and quantification of nuclear factor kappa B (NF-kB) expression. In addition, cytotoxicity testing and assessment of locomotor potential will be included. Thus, this work will contribute to a better understanding of the action of indomethacin incorporated into mesoporous silica nanoparticles, providing its most effective and safe use in future clinical applications. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JUNIOR, SILVIO ALMEIDA; PEREIRA, POLIANA MARQUES; TOTOLI, VANESSA DE SOUZA; NEVES, EDNA SOUSA; MONOCHIO, MAYARA; ALVARENGA, ALEF WINTER OLIVEIRA; HORI, JULIANA ISSA; BRAZ, WILSON RODRIGUES; ROCHA, LUCAS ALONSO; NASSAR, EDUARDO JOSE; et al. Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica. European Journal of Pharmaceutical Sciences, v. 157, FEB 1 2021. (18/00840-2, 17/10241-6, 17/22919-7)