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Effect of photobiomodulation on local reaction induced by Bothrops venom: mechanisms of muscle regeneration, inflammatory response and oxidative stress

Grant number: 17/13503-1
Support type:Regular Research Grants
Duration: November 01, 2017 - October 31, 2019
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Principal researcher:Stella Regina Zamuner
Grantee:Stella Regina Zamuner
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil


The envenoming caused by snakes of the genus Bothrops is often associated with serious and complex pathological manifestations, which includes pain, swelling, inflammatory process, hemorrhage and myonecrosis. The specific treatment for botropic accident is the use of antivenom therapy, which performs the function of neutralizing the largest possible amount of venom in the circulation, however its action does not extend to local manifestations causing permanent tissue loss and, in some cases, amputation of the victim's affected limb. Thus, there is an important need to find therapies that can complement antivenoms in the neutralization of local tissue damage. Currently, data from the literature show that photobiomodulation (PBM), with low level laser or LED, is an alternative treatment in situations of muscle injury due to its analgesic, anti-inflammatory and cicatrizing effects. In addition, PBM can be considered an effective therapeutic tool in snakebite patients. Although the literature presents studies dedicated to the use of PBM to understand its role in the local effect of envenomation, particularly of the genus Bothrops, its mechanism of action is poorly understood. The present proposal aims to collaborate with the understanding of the effect of FBM on the mechanism of muscle regeneration, inflammatory response and oxidative stress after botrops venom lesion. Thus, this study may provide important insights for possible innovative strategies in the adjuvant treatment of antivenom and consequently a better alternative for the treatment of ophidian envenoming. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOUVEIA, VIVIANE ALMEIDA; FERREIRA SOARES PISETE, FLAVIA REGINA; ROCHA WAGNER, CRISTIANE LUIZE; DALBONI, MARIA APARECIDA; LIGEIRO DE OLIVEIRA, ANA PAULA; COGO, JOSE CARLOS; ZAMUNER, STELLA REGINA. Photobiomodulation reduces cell death and cytokine production in C2C12 cells exposed to Bothrops venoms. Lasers in Medical Science, v. 35, n. 5 NOV 2019. Web of Science Citations: 0.
GONSALVES SILVA, LUCIANA MIATO; ZAMUNER, LUIS FERNANDO; DAVID, AMANDA CABRAL; DOS SANTOS, SOLANGE A.; CAMILO DE CARVALHO, PAULO DE TARSO; ZAMUNER, STELLA REGINA. Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review. Toxicon, v. 152, p. 23-29, SEP 15 2018. Web of Science Citations: 2.

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