Evaluation of spontaneous physical activity and compensatory behavior in experimental model and obese individuals engaged in an interdisciplinary program for obesity treatment

• Grant number: 17/04528-0
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2017 - November 30, 2019
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Camila Aparecida Machado de Oliveira
• Grantee: Camila Aparecida Machado de Oliveira
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Danielle Arisa Caranti ; Isabel Cristina Céspedes ; Luciana Le Sueur Maluf ; Ricardo Jose Gomes

Abstract

In addition to the association between low levels of physical activity and obesity, physical inactivity is a risk factor for a large number of chronic-degenerative diseases and premature mortality. Currently, however, the continuing focus of research on moderate and vigorous physical activity for health is being questioned. Light-intensity physical activities of daily life, known as spontaneous physical activities (AFE), contribute substantially to total daily energy expenditure and to reduce sedentary behaviors. Despite this, the study of AFE has been neglected. We have been committed to expand the knowledge on AFE. We recently demonstrated a compensatory reduction of AFE in response to voluntary exercise in mice. This compensation decreases efficiency of exercise as a tool for reducing body weight. We also observed that the drop in AFE which occurs with ageing is related to reduced action of leptin on hypothalamus. We intend to continue these studies, acting on two fronts. In the first, we will characterize compensatory changes in AFE in response to acute voluntary exercise as the mice age (4 to 10 months of age) and evaluate hypothalamic and extra hypothalamic regions that participate in the regulation of locomotion in both young and aged mice. And since a caloric restriction of 30% seems to prevent a decrease in locomotion during age, we will also use a group of mice submitted to calorie restriction. In the second front, we will evaluate, in obese adults, the effects of an interdisciplinary program for obesity treatment on AFE and if the change in AFE influence the success of the program based on anthropometric and biochemical analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BENFATO, IZABELLE DIAS; SILVARES QUINTANILHA, ANA CAROLINA; HENRIQUE, JESSICA SALLES; SOUZA, MELYSSA ALVES; ROSARIO, BARBARA DOS ANJOS; ARAUJO BESERRA FILHO, JOSE IVO; OLIVEIRA SANTOS, ROBSON LUIZ; RIBEIRO, ALESSANDRA MUSSI; MALUF, LUCIANA LE SUEUR; MACHADO DE OLIVEIRA, CAMILA APARECIDA. Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice. Behavioural Brain Research, v. 417, JAN 24 2022. (17/26075-8, 17/04528-0, 11/05932-3)

DE OLIVEIRA, CAMILA A. M.; VILLANI, MARIANA C.; MESSIAS, CAIO B.; MORAES, AMANDA S.; GIL, SILVANDRO S.; CUESTA, MARIA GABRIELA S.; AFFONSO, LUIZ HENRIQUE L.; TEIXEIRA, SUZANA M. R.; TEIXEIRA, CAUE V. LA SCALA; GOMES, RICARDO J.; et al. Sedentary Time and Physical Activity Pattern in Women after an Interdisciplinary Program to Treat Obesity. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 51, n. 6, p. 1-pg., 2019-06-01. (15/06630-1, 17/04528-0)

SILVARES QUINTANILHA, ANA CAROLINA; BENFATO, IZABELLE DIAS; OLIVEIRA SANTOS, ROBSON LUIZ; MOREIRA ANTUNES, HANNA KAREN; MACHADO DE OLIVEIRA, CAMILA APARECIDA. Effects of acute exercise on spontaneous physical activity in mice at different ages. BMC SPORTS SCIENCE MEDICINE AND REHABILITATION, v. 13, n. 1, JUL 27 2021. (11/05932-3, 17/04528-0)