Global screening of genetic and epigenetic factors associated with magnitude of response to different physical training protocols in women 50-70 years

• Grant number: 17/21361-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2018
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Roberto Bueno Júnior
• Grantee: Carlos Roberto Bueno Júnior
• Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated researchers: Carla Barbosa Nonino ; Carlos Ugrinowitsch

Abstract

The World Health Organization estimates that the world population over 60 years of age will increase from the current 841 million to two billion by 2050, making chronic diseases and the welfare of the elderly the new global public health challenge. A great scientific question unanswered in exercise science, which has a strong relation with this context, is the type of training that can generate greater benefits in each individual; although companies already sell genetic tests for this purpose, they fail to satisfy key criteria for scientific validity. The studies in the literature used only aerobic physical exercise, did not compare different types of stimuli, and did not associate data from global genetic variants to DNA methylation profile. The main purpose of this study is to evaluate anthropometric measures, blood pressure, bone mineral mass, muscle mass, body composition (DXA), maximal oxygen consumption, tests of muscular strength, functional performance, quality of life, and blood variables in women of 50 to 70 years and analyze: a. the effects of combined versus multicomponent physical exercise acutely and chronically on the global blood DNA methylation profile through Illumina's 850k Infinium MethylationEPIC BeadChip; and b. global genetic variants (Infinium Global Screening Array-24 v1.0 BeadChip of the Illumina platform) and methylation profile of blood DNA following a single session of physical exercise as predictors of magnitude of response in each of the two training protocols. This study will allow the achievement of subsidies for a paradigm shift associated with the prescription of personalized physical training. (AU)

Scientific publications

(14)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DA SILVA SOBRINHO, ANDRESSA CRYSTINE; DE ALMEIDA, MARIANA LUCIANO; RODRIGUES SILVA, VAGNER RAMON; RODRIGUES, GUILHERME DA SILVA; RODRIGUES, KARINE PEREIRA; MONTEIRO, CAMILA DE PAULA; BUENO JUNIOR, CARLOS ROBERTO. Quality of Movement Is Associated With Cognitive Function in Physically Inactive Older Women. JOURNAL OF AGING AND PHYSICAL ACTIVITY, v. 29, n. 5, p. 822-827, OCT 2021. (17/21361-2)

SOBRINHO, ANDRESSA CRYSTINE DA SILVA; RODRIGUES, GUILHERME DA SILVA; DE OLIVEIRA, GUILHERME LIMA; GOMES, GRACE ANGELICA DE OLIVEIRA; BUENO JUNIOR, CARLOS ROBERTO. Everyday Digital Support to Promote Health and Literacy Among Older Adults: 14-Week Randomized Digital Pilot Trial by Engagement Level. JMIR FORMATIVE RESEARCH, v. 9, p. 14-pg., 2025-01-01. (17/21361-2)

SOBRINHO, ANDRESSA CRYSTINE DA SILVA; RODRIGUES, GUILHERME DA SILVA; RODRIGUES, KARINE PEREIRA; FINZETO, LARISSA CHACON; SAMPAIO, LAURA T. D. V.; DANIEL, GUILHERME CARVALHO; DE FREITAS, JOAO PAULO; DE LIMA, JOAO GABRIEL RIBEIRO; GOMES, GRACE ANGELICA OLIVEIRA; BUENO JUNIOR, CARLOS ROBERTO. Transforming daily support with multidisciplinary teleassistance: impact on health parameters in older adults-a randomized controlled trial. MHEALTH, v. 11, p. 21-pg., 2025-07-01. (17/21361-2)

RODRIGUES, GUILHERME DA SILVA; NORONHA, NATALIA Y.; ALMEIDA, MARIANA L.; SOBRINHO, ANDRESSA C. DA S.; WATANABE, LIGIA M.; PINHEL, MARCELA A. DE S.; DE LIMA, JOAO G. R.; ZHANG, REN; NONINO, CARLA B.; ALVES, CHRISTIANO R. R.; et al. Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women. Journal of Applied Physiology, v. 134, n. 3, p. 12-pg., 2023-03-01. (17/21361-2)

CORREIA, IGOR MASSARI; DA SILVA RODRIGUES, GUILHERME; NORONHA, NATALIA YUMI; WATANABE, LIGIA MORIGUCHI; LUCIANO DE ALMEIDA, MARIANA; SOBRINHO, ANDRESSA CRYSTINE DA SILVA; NONINO, CARLA BARBOSA; BUENO JUNIOR, CARLOS ROBERTO. An anti-isomorphism between Brauer-Clifford-Long groups BD(S, H) and BD(S-op, H-*). FRONTIERS IN PHYSIOLOGY, v. 14, p. 11-pg., 2023-04-10. (17/21361-2)

NORONHA, NATALIA YUMI; RODRIGUES, GUILHERME DA SILVA; YONEHARA NOMA, ISABELLA HARUMI; CUNHA BRANDAO, CAMILA FERNANDA; RODRIGUES, KARINE PEREIRA; BRUNO, ALEXANDRE COLELLO; SAE-LEE, CHANACHAI; WATANABE, LIGIA MORIGUCHI; DE SOUZA PINHEL, MARCELA AUGUSTA; SCHINEIDER, ISABELLE MELLO; et al. 14-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes. FRONTIERS IN ENDOCRINOLOGY, v. 13, p. 15-pg., 2022-08-15. (20/08687-9, 17/21361-2, 18/24069-3)

KARINE P. RODRIGUES; LAIS S. PRADO; MARIANA LUCIANO DE ALMEIDA; ATILA ALEXANDRE TRAPE; CARLOS ROBERTO BUENO JUNIOR. Association between ACE and ACTN3 genetic polymorphisms and the effects of different physical training models on physically active women aged 50 to 75. Anais da Academia Brasileira de Ciências, v. 94, 2022-10-03. (17/21361-2, 13/21159-8)

SOBRINHO, ANDRESSA CRYSTINE DA SILVA; GOMES, GRACE ANGELICA DE OLIVEIRA; BUENO JUNIOR, CARLOS ROBERTO. Developing a Multiprofessional Mobile App to Enhance Health Habits in Older Adults: User-Centered Approach. JMIR FORMATIVE RESEARCH, v. 8, p. 16-pg., 2024-01-01. (17/21361-2)

RODRIGUES, GUILHERME DA SILVA; NOMA, ISABELLA HARUMI YONEHARA; NORONHA, NATALIA YUMI; WATANABE, LIGIA MORIGUCHI; SOBRINHO, ANDRESSA CRYSTINE DA SILVA; DE LIMA, JOAO GABRIEL RIBEIRO; SAE-LEE, CHANACHAI; BENJAMIM, CICERO JONAS RODRIGUES; NONINO, CARLA BARBOSA; BUENO JUBUIR, CARLOS ROBERTO. Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women. RESEARCH QUARTERLY FOR EXERCISE AND SPORT, v. N/A, p. 11-pg., 2023-07-21. (17/21361-2)

RODRIGUES, GUILHERME DA SILVA; NORONHA, NATALIA YUMI; NOMA, ISABELLA HARUMI YONEHARA; DE LIMA, JOAO GABRIEL RIBEIRO; SOBRINHO, ANDRESSA CRYSTINE DA SILVA; PINHEL, MARCELA AUGUSTA DE SOUZA; DE ALMEIDA, MARIANA LUCIANO; WATANABE, LIGIA MORIGUCHI; NONINO, CARLA BARBOSA; BUENO JUNIOR, CARLOS ROBERTO. 14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years. Experimental Gerontology, v. 186, p. 9-pg., 2024-01-18. (17/21361-2)

DAWANGPA, ATCHARA; CHITTA, PITAKSIN; RODRIGUES, GUILHERME DA SILVA; IADSEE, NUTTA; NORONHA, NATALIA Y.; NONINO, CARLA B.; BUENO JUNIOR, CARLOS R.; SAE-LEE, CHANACHAI. Impact of combined exercise on blood DNA methylation and physical health in older women with obesity. PLoS One, v. 19, n. 12, p. 22-pg., 2024-12-16. (20/08687-9, 18/24069-3, 17/21361-2)

RODRIGUES, KARINE PEREIRA; PRADO, LAIS; DE ALMEIDA, MARIANA LUCIANO; YAMADA, ANDRE KATAYAMA; FINZETO, LARISSA CHACON; BUENO JUNIOR, CARLOS ROBERTO. Effects of Combined Versus Multicomponent Training in Physically Active Women Aged 50-75 Years. RESEARCH QUARTERLY FOR EXERCISE AND SPORT, OCT 2021. (17/21361-2)

SOBRINHO, ANDRESSA CRYSTINE DA SILVA; DE ALMEIDA, MARIANA LUCIANO; RODRIGUES, GUILHERME DA SILVA; FINZETO, LARISSA CHACON; SILVA, VAGNER RAMON RODRIGUES; BERNATTI, RODRIGO FENNER; BUENO JUNIOR, CARLOS ROBERTO. Effect of Flexibility Training Associated with Multicomponent Training on Posture and Quality of Movement in Physically Inactive Older Women: A Randomized Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 20, OCT 2021. (13/21159-8, 17/21361-2)

PORTO GONCALVES, THIAGO CORREA; TRAPE, ATILA ALEXANDRE; LIMA RODRIGUES, JHENNYFER ALINE; TAVARES, SIMONE SAKAGUTE; BUENO JUNIOR, CARLOS ROBERTO. Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of beta(2) Adrenergic Receptor Haplotypes. JOURNAL OF AGING AND PHYSICAL ACTIVITY, v. 28, n. 2, p. 242-249, APR 2020. (13/21159-8, 17/21361-2)