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Global screening of genetic and epigenetic factors associated with magnitude of response to different physical training protocols in women 50-70 years

Abstract

The World Health Organization estimates that the world population over 60 years of age will increase from the current 841 million to two billion by 2050, making chronic diseases and the welfare of the elderly the new global public health challenge. A great scientific question unanswered in exercise science, which has a strong relation with this context, is the type of training that can generate greater benefits in each individual; although companies already sell genetic tests for this purpose, they fail to satisfy key criteria for scientific validity. The studies in the literature used only aerobic physical exercise, did not compare different types of stimuli, and did not associate data from global genetic variants to DNA methylation profile. The main purpose of this study is to evaluate anthropometric measures, blood pressure, bone mineral mass, muscle mass, body composition (DXA), maximal oxygen consumption, tests of muscular strength, functional performance, quality of life, and blood variables in women of 50 to 70 years and analyze: a. the effects of combined versus multicomponent physical exercise acutely and chronically on the global blood DNA methylation profile through Illumina's 850k Infinium MethylationEPIC BeadChip; and b. global genetic variants (Infinium Global Screening Array-24 v1.0 BeadChip of the Illumina platform) and methylation profile of blood DNA following a single session of physical exercise as predictors of magnitude of response in each of the two training protocols. This study will allow the achievement of subsidies for a paradigm shift associated with the prescription of personalized physical training. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA SOBRINHO, ANDRESSA CRYSTINE; DE ALMEIDA, MARIANA LUCIANO; RODRIGUES SILVA, VAGNER RAMON; RODRIGUES, GUILHERME DA SILVA; RODRIGUES, KARINE PEREIRA; MONTEIRO, CAMILA DE PAULA; BUENO JUNIOR, CARLOS ROBERTO. Quality of Movement Is Associated With Cognitive Function in Physically Inactive Older Women. JOURNAL OF AGING AND PHYSICAL ACTIVITY, v. 29, n. 5, p. 822-827, OCT 2021. Web of Science Citations: 0.
PORTO GONCALVES, THIAGO CORREA; TRAPE, ATILA ALEXANDRE; LIMA RODRIGUES, JHENNYFER ALINE; TAVARES, SIMONE SAKAGUTE; BUENO JUNIOR, CARLOS ROBERTO. Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of beta(2) Adrenergic Receptor Haplotypes. JOURNAL OF AGING AND PHYSICAL ACTIVITY, v. 28, n. 2, p. 242-249, APR 2020. Web of Science Citations: 0.

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