Mechanical and microbiological characterization of the novel bioactive composites

• Grant number: 17/50290-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2018
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Agreement: University of New South Wales
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Flavia Gonçalves
• Grantee: Flavia Gonçalves
• Principal researcher abroad: Lamie Kruzic
• Institution abroad: University of New South Wales (UNSW), Australia
• Host Institution: Universidade Ibirapuera (UNIB). Campus Chácara Flora. São Paulo , SP, Brazil

Abstract

Recurrent caries are one of the main reasons for resin composite restorations failures. There is currently a need to develop improved and longer lasting dental restorative materials with the ability to self-heal while resisting recurrent caries via an antimicrobial effect. The current FAPESP regular grant, aims to develop a bioactive restorative composite with antimicrobial and remineralizing properties using chitosan nanospheres loaded with calcium phosphate. However, more studies are needed to improve our understanding of the mechanical properties, microstructure and mechano-biological performance of these novel restorative materials. Accordingly, the UNSW team aims to use their novel methodologies to evaluate the in vitro composite mechanical performance. Their unique methodology enables mechanical testing in a simulated oral-like environment, which includes the microbiological, physical, and chemical factors experienced in the oral environment. Moreover, the proposed collaboration with the FAPESP project will provide the UNSW team unique access to knowledge regarding chitosan nanosphere applications for dental materials. The nanotechnology, which can delivery not only calcium phosphate but several drugs and growth factors of interest, also has the potential to be transferred to different matrix materials, such as resin-modified glass ionomer (RMGIC), an area of current research interest to the UNSW team. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOPES, DIANA PEREIRA; FREITAS, SELMA REGINA MUNIZ; TANAKA, CARINA BAPTISTON; DELECHIAVE, GIOVANNE; KIKUCHI, LUCIA NOBUCO TAKAMORI; BRAGA, ROBERTO R.; KRUZIC, JAMIE J.; MOREIRA, MARIA STELLA; BOARO, LETICIA CRISTINA CIDREIRA; CATALANI, LUIZ HENRIQUE; et al. Synthesis of Submicrometric Chitosan Particles Loaded with Calcium Phosphate for Biomedical Applications. AAPS PHARMSCITECH, v. 24, n. 2, p. 9-pg., 2023-02-09. (16/13114-2, 17/50290-6)

KRUZIC, JAMIE J.; ARSECULARATNE, JOSEPH A.; TANAKA, CARINA B.; HOFFMAN, MARK J.; CESAR, PAULO F.. Recent advances in understanding the fatigue and wear behavior of dental composites and ceramics. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 88, p. 504-533, DEC 2018. (17/11913-8, 17/50290-6)

Filed patent(s) as a result of this research project