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Production and characterization of composite biomaterials based on calcium aluminate cement for applications in medical-dental health

Grant number: 13/22502-8
Support type:Regular Research Grants
Duration: February 01, 2014 - January 31, 2016
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Ivone Regina de Oliveira
Grantee:Ivone Regina de Oliveira
Home Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Assoc. researchers: Marcos Jacobovitz ; Paulo Tambasco de Oliveira


Calcium aluminate cement (CAC) has been studied as a repair material in endodontics. CAC shows advantages in the physical and mechanical properties, bioactivity when exposed to simulated body fluid solution, and as a barrier against physical and chemical microleakage. Furthermore, through developing the project "Systematic physico-chemical study on cement material for its application as biomaterial," it was possible to determine the influence of additives on its hydration reaction, pH in biological fluid solution, workability/setting time, bioactivity, injectability, and radiopacity. The present study aims to produce biomaterial based on CAC to meet the recommendations of the report of the Prospective Study in Advanced Materials for Applications in Medical-Dental Health to develop cements with potential applications for replacing the glass ionomer cement and materials to be used in the production of scaffolds for tissue engineering. In Brazil, ionomers are imported and only packaged in the country. Furthermore, the engineering of tissue for cartilage and bone depends on a biomaterial that serves as a scaffold for cell culturing and development of new tissue. In this area, compatibility between the mechanical and biological properties has not yet been fully achieved. Thus, some compounds will be incorporated into the CAC to increase the mechanical strength and biocompatibility with biological systems for application in medical/dental health. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, I. R.; RANIERO, L. J.; LEITE, V. M. C.; CASTRO-RAUCCI, L. M. S.; DE OLIVEIRA, P. T.; PANDOLFELLI, V. C. In vitro apatite-forming ability of calcium aluminate blends. CERAMICS INTERNATIONAL, v. 43, n. 13, p. 10071-10079, SEP 2017. Web of Science Citations: 4.
PARREIRA, R. M.; ANDRADE, T. L.; LUZ, A. P.; PANDOLFELLI, V. C.; OLIVEIRA, I. R. Calcium aluminate cement-based compositions for biomaterial applications. CERAMICS INTERNATIONAL, v. 42, n. 10, p. 11732-11738, AUG 1 2016. Web of Science Citations: 12.
OLIVEIRA, I. R.; ANDRADE, T. L.; ARAUJO, K. C. M. L.; LUZ, A. P.; PANDOLFELLI, V. C. Hydroxyapatite synthesis and the benefits of its blend with calcium aluminate cement. CERAMICS INTERNATIONAL, v. 42, n. 2, A, p. 2542-2549, FEB 1 2016. Web of Science Citations: 11.
DE OLIVEIRA, IVONE REGINA; CESAR LEITE, VITORIA MARQUES; VARGAS PORTO LIMA, MILENE PAULA; SALOMAO, RAFAEL. Production of porous ceramic material using different sources of alumina and calcia. MATERIA-RIO DE JANEIRO, v. 20, n. 3, p. 739-746, JUL-SEP 2015. Web of Science Citations: 7.
DE OLIVEIRA, IVONE REGINA; DE ANDRADE, TALITA LUANA; PARREIRA, RENATA MARTINS; JACOBOVITZ, MARCOS; PANDOLFELLI, VICTOR CARLOS. Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 18, n. 2, p. 382-389, MAR-APR 2015. Web of Science Citations: 5.
IVONE REGINA DE OLIVEIRA; VITORIA MARQUES CESAR LEITE; MILENE PAULA VARGAS PORTO LIMA; RAFAEL SALOMÃO. Production of porous ceramic materialusing different sources of alumina and calcia. MATERIA-RIO DE JANEIRO, v. 20, n. 3, p. 739-746, Set. 2015.

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