Design of new (multi)-dedicated silica nanoparticles based on ionic liquids for biomedical applications

• Grant number: 17/26471-0
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: June 01, 2018
• End date: November 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Mateus Borba Cardoso
• Grantee: Mateus Borba Cardoso
• Visiting researcher: Sébastien Livi
• Visiting researcher institution: Institut National des Sciences Appliquées Lyon (INSA Lyon), France
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated research grant: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM

Abstract

The objective of this project is to design new functionalized silica nanoparticles (NPs) by using ionic liquids (ILs) based on imidazolium salts to avoid unspecific protein adsorption (protein corona). To overcome this challenge, various silylated ILs combined with different reactive functions (amine, acid) and counter anions will be synthetized, characterized and, then, grafted on silica NPs. Thus, the influence of the surface treatments as well as the diameter of the silica NPs will be investigated by TEM and SAXS, the thermal stability by TGA, the stability/aggregation by DLS-Zeta potential and the NIMs rheological properties by standard rheology measurements. In addition, their behavior in biological fluids will be also studied "in situ" by infrared synchrotron-based techniques and small angle X-ray scattering which will allow drawing a better understanding on the protein corona formation. Finally, the biological activities of these new silica NPs and the ultimate biological effect of protein corona will be deeply studied. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIVI, SEBASTIEN; LINS, LUANDA C.; CAPELETTI, LARISSA B.; CHARDIN, CHARLINE; HALAWANI, NOUR; BAUDOUX, JEROME; CARDOSO, MATEUS B.. Antibacterial surface based on new epoxy-amine networks from ionic liquid monomers. EUROPEAN POLYMER JOURNAL, v. 116, p. 56-64, JUL 2019. (17/11060-5, 17/26471-0, 15/25406-5, 17/01167-7)