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Polymeric matrices of cross-linked high amylose and pectin for controlled release of nimesulide

Grant number: 08/01901-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2008
Effective date (End): July 31, 2010
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Raul Cesar Evangelista
Grantee:Fernanda Mansano Carbinatto
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


The majority of medicines administered by the oral route is in the solid form and, among them, tablets represent 80% of the world market. Controlled drug delivery systems (CDDS), specially the solid forms obtained from hydrophilic matrices, play important role due to the possibility of incorporation of great amounts of drug, economy and easy of processing and allowing reproducible drug release profiles. The properties of hydrophylic polymers can be altered by cross-linking, originating hydrogels, which are swellable in aqueous media, making possible the effective control of drug release. Recently, in our laboratories, high amylose was cross-linked by reaction with sodium trimetaphosphate (TMPS), originating non-compacted solid systems, which prolonged dichlofenac release up to 24 h. Pectin can also be cross-linked with the same reagent and, inclusive, in mixtures with high amylose. However, such excipient has not yet been used for the preparation of CDDS. Thus, the objective of this project is to cross-link the referred polymers, isolated and in mixtures and extensively characterize the products, with which matrix tablets containing nimesulide, a class II model drug (low solubility and high permeability) will be prepared. The tablets will be characterized in relation to physical properties and "in vitro" drug release, which mechanisms will be analyzed by mathematical models.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARBINATTO, FERNANDA M.; DE CASTRO, ANA DORIS; CURY, BEATRIZ S. F.; MAGALHAES, ALVICLER; EVANGELISTA, RAUL C.. Physical properties of pectin-high amylose starch mixtures cross-linked with sodium trimetaphosphate. International Journal of Pharmaceutics, v. 423, n. 2, p. 281-288, . (08/01901-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CARBINATTO, Fernanda Mansano. Matrizes poliméricas reticuladas de alta amilose e pectina para liberação controlada de fármacos. 2010. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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