Levels of interferon alpha, gamma and TNF alpha in patients of SLE: association with clinical manifestations

• Grant number: 09/11076-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2010
• End date: February 29, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Simone Appenzeller
• Grantee: Mariana Postal Zink de Souza
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune multisystemic disease characterized by periods of activity and remission. The clinical manifestations more frequently observed are skin lesions, photosensitivity, oral ulcers, arthritis, serositis, renal and neurological involvement. The central nervous system is frequently involved, and manifestations as seizures, mood disorders, headaches, and neuropathies can be observed in variable frequencies.Laboratory involvement includes hematological abnormalities such as leucopenia and hemolytic anemia and immunological features. Laboratory features support the diagnosis and helps determining disease activity. This cross-sectional study aims to compare the levels of interferon alpha and gamma and tumor necrosis factor (TNF) in 100 patients with SLE to 20 first-degree relatives and to 20 healthy volunteers. We also aim to correlate these findings to the clinical manifestations of SLE, disease activity and end-organ damage. Levels of interferon, both alpha and gamma and TNF will be measured from peripheral blood samples (serum) by the method of Enzyme Linked Immuno Sorbent Assay (ELISA).

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARIANA POSTAL; NAILU ANGÉLICA SINICATO; KARINA OLIVEIRA PELIÇARI; ROBERTO MARINI; LILIAN TEREZA LAVRAS COSTALLAT; SIMONE APPENZELLER. Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus. Clinics, v. 67, n. 2, p. 157-162, 2012-00-00. (09/11076-2, 10/13636-2, 08/02917-0, 09/06049-6, 10/13637-9)

POSTAL, MARIANA; COSTALLAT, LILIAN T. L.; APPENZELLER, SIMONE. Neuropsychiatric Manifestations in Systemic Lupus Erythematosus Epidemiology, Pathophysiology and Management. CNS DRUGS, v. 25, n. 9, p. 721-736, 2011. (09/06049-6, 09/11076-2)

POSTAL, MARIANA; APPENZELLER, SIMONE. The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. CYTOKINE, v. 56, n. 3, p. 537-543, DEC 2011. (09/06049-6, 08/02917-0, 09/11076-2)

BARBOSA, RENATA; POSTAL, MARIANA; COSTALLAT, LILIAN TEREZA LAVRAS; CENDES, FERNANDO; APPENZELLER, SIMONE. Cognitive Impairment in Systemic Lupus Erythematosus: Prevalence and Clinical Importance. CURRENT RHEUMATOLOGY REVIEWS, v. 8, n. 1, p. 10-pg., 2012-01-01. (10/13639-1, 09/11076-2)

POSTAL, MARIANA; SINICATO, NAILU ANGELICA; PELICARI, KARINA OLIVEIRA; MARINI, ROBERTO; LAVRAS COSTALLAT, LILIAN TEREZA; APPENZELLER, SIMONE. Clinical and serological manifestations associated with interferon-alpha levels in childhood-onset systemic lupus erythematosus. Clinics, v. 67, n. 2, p. 157-162, 2012. (10/13636-2, 09/11076-2, 09/06049-6, 08/02917-0, 10/13637-9)

COSTALLAT, GUILHERME LAVRAS; APPENZELLER, SIMONE; LAVRAS COSTALLAT, LILIAN TEREZA. Evans syndrome and Systemic Lupus Erythematosus: Clinical presentation and outcome. JOINT BONE SPINE, v. 79, n. 4, p. 362-364, JUL 2012. (09/11076-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUZA, Mariana Postal Zink de. Sera levels of interferon alpha and tumor necrosis factor alpha in childhood-onset systemic lupus erythematosus patients: association with clinical manifestations. 2012. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.