Antischistosomal and antileishmanial in vitro activities of some dihydrobenzofuran lignans

• Grant number: 09/12202-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2010
• End date: February 29, 2012
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Antônio Eduardo Miller Crotti
• Grantee: Murilo de Jesus Fukui
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Lignans e neolignans have attracted much interest over the years on account of their broad range of biological activities. Previous biological activities showed that tetrahydrofuran and dibenzylbutirolactone lignans possess in vitro and in vivo antischistossomial activities. Then, the aims of this project are: to obtain the dihydrobenzofuran lignans and neolignans 1a-1b, 2a-2b and 3a-3b, as well as to evaluate the in vitro antischistossomial and leishmanicidal activities of these synthesized compounds. These compounds will be obtained by in vitro oxidative coupling using different phenylpropanoids. After synthesized, these compounds will be purified using several techniques, including chromatographic methods, and identified by spectroscopic analysis (p. ex. RMN 1H and 13C). All obtained compounds will be evaluted in the in vitro antischistossomial and leishmanicidal assays. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MEDEIROS, TALITA C. T.; DIAS, HERBERT J.; SILVA, ELIANE O.; FUKUI, MURILO J.; SOARES, ANA CAROLINA F.; KAR, TAPAS; HELENO, VLADIMIR C. G.; DONATE, PAULO M.; PARREIRA, RENATO L. T.; CROTTI, ANTONIO E. M.. Detailed H-1 and C-13 NMR Spectral Data Assignment for Two Dihydrobenzofuran Neolignans. Journal of the Brazilian Chemical Society, v. 27, n. 1, p. 136-143, JAN 2016. (13/20094-0, 11/07623-8, 09/12202-1)

TALITA C. T. MEDEIROS; HERBERT J. DIAS; ELIANE O. SILVA; MURILO J. FUKUI; ANA CAROLINA F. SOARES; TAPAS KAR; VLADIMIR C. G. HELENO; PAULO M. DONATE; RENATO L. T. PARREIRA; ANTÔNIO E. M. CROTTI. Detailed 1H and 13C NMR Spectral Data Assignment for Two Dihydrobenzofuran Neolignans. Journal of the Brazilian Chemical Society, v. 27, n. 1, p. 136-143, 2016-01-00. (11/07623-8, 09/12202-1, 13/20094-0)

DIAS, HERBERT J.; PATROCINIO, ANDRESSA B.; PAGOTTI, MARIANA C.; FUKUI, MURILO J.; RODRIGUES, VANDERLEI; MAGALHAES, LIZANDRA G.; CROTTI, ANTONIO E. M.. Schistosomicidal Activity of Dihydrobenzofuran Neolignans. CHEMISTRY & BIODIVERSITY, v. 15, n. 7, JUL 2018. (13/20094-0, 09/12202-1, 13/11164-4, 16/24456-1, 14/50265-3)

FUKUI, MURILO J.; DIAS, HERBERT J.; SEVERIANO, MARCELA E.; DE SOUZA, MARIA G. M.; DE OLIVEIRA, POLLYANNA F.; AMBROSIO, SERGIO R.; MARTINS, CARLOS H. G.; TAVARES, DENISE C.; CROTTI, ANTONIO E. M.. Antimicrobial and Cytotoxic Activity of Dihydrobenzofuran Neolignans. CHEMISTRYSELECT, v. 3, n. 6, p. 1836-1839, FEB 14 2018. (13/20094-0, 09/12202-1)