Boron-Doped Diamond Electrode for the Determination Voltametric/ Amperometric of Anti-Helmintic and antihypertensive Drugs

• Grant number: 09/17729-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2010
• End date: June 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Orlando Fatibello Filho
• Grantee: Bruna Cláudia Lourenção
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The anthelmintic drug are classes of great importance for the treatment of humans as well as for the treatment of animals. However, these drugs are often used in an uncontrolled manner, may compromise the health of individuals who are ingesting. Thus, it is extremely important to develop analytical procedures that are simple, fast and accurate for identifying, measuring or monitoring of these drugs in urine, food of animal origin (milk, eggs) and pharmaceuticals.In this work will be developed electroanalytical methods for the determination of drug albendazole, ivermectin and febantel employing cyclic voltammetry, square wave and differential pulse electrode and boron-doped diamond (BDD), with or without modification, as electrode work Furthermore, it will develop a system stream with amperometric detection and multiple pulse amperometric for determining these drugs.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOURENCAO, BRUNA C.; MEDEIROS, ROBERTA A.; THOMASI, SERGIO SCHERRER; FERREIRA, ANTONIO GILBERTO; ROCHA-FILHO, ROMEU C.; FATIBELLO-FILHO, ORLANDO. Amperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes. SENSORS AND ACTUATORS B-CHEMICAL, v. 222, p. 181-189, JAN 2016. (09/17729-8, 14/03019-7, 11/00601-9)

LOURENCAO, BRUNA C.; MEDEIROS, ROBERTA A.; FATIBELLO-FILHO, ORLANDO. Simultaneous determination of antihypertensive drugs by flow injection analysis using multiple pulse amperometric detection with a cathodically pretreated boron-doped diamond electrode. Journal of Electroanalytical Chemistry, v. 754, p. 154-159, OCT 1 2015. (09/17729-8, 14/03019-7)

LOURENCAO, BRUNA C.; SILVA, TIAGO A.; FATIBELLO-FILHO, ORLANDO; SWAIN, GREG M.. Voltammetric Studies of Propranolol and Hydrochlorothiazide Oxidation in Standard and Synthetic Biological Fluids Using a Nitrogen-Containing Tetrahedral Amorphous Carbon (ta-C:N) Electrode. Electrochimica Acta, v. 143, p. 398-406, OCT 10 2014. (09/17729-8)

LOURENCAO, BRUNA C.; BACCARIN, MARINA; MEDEIROS, ROBERTA A.; ROCHA-FILHO, ROMEU C.; FATIBELLO-FILHO, ORLANDO. Differential pulse voltammetric determination of albendazole in pharmaceutical tablets using a cathodically pretreated boron-doped diamond electrode. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 707, p. 15-19, OCT 15 2013. (09/17729-8, 11/00601-9)

LOURENCAO, BRUNA C.; MEDEIROS, ROBERTA A.; FATIBELLO-FILHO, ORLANDO. Simultaneous determination of antihypertensive drugs by flow injection analysis using multiple pulse amperometric detection with a cathodically pretreated boron-doped diamond electrode. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 754, p. 6-pg., 2015-10-01. (09/17729-8, 14/03019-7)