Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives.

• Grant number: 10/02887-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2010
• End date: February 29, 2012
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Leoberto Costa Tavares
• Grantee: Fanny Palace Berl
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The search for alternative therapies for the treatment of Chagas disease is very important, since currently there are only two drugs available, benznidazole and nifurtimox. Both of them have considerable adverse effects, and only benznidazole is used in Brazil. In addition, these drugs are ineffective in the chronic phase. The need to search for new alternatives to combat Chagas disease is evident and nitro-heterocyclic derivatives with activity against Trypanosoma cruzi, the causative agent of Chagas disease, are a very viable alternative for studies of new lead-compound. A strategy for identification of promising new compounds is the molecular modification of drugs wich are available for therapy, aiming to improve pharmacodynamic and pharmacokinetic aspects. In this context, this study proposes the design, synthesis, identification and evaluation of biological activity of furfuryliden derivatives against T. cruzi. The results of the synthesized compounds activity against epimastigotes forms of T. cruzi will applied to study the structure-activity relationships in order to verify the influence of physicochemical properties that most influence on biological activity.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BERL, Fanny Palace. Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives. 2012. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.