Bioglasses derived from 45S5: effects of Nb2O5 or surface modification with Ca2+ on the glass structure and bioactivity

• Grant number: 10/05394-9
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2010
• Effective date (End): January 19, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Celso Aparecido Bertran
• Grantee: João Henrique Lopes
• Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 13/12376-5 - Bone formation controlled by biologically active inorganic ions: investigation of the role and controlled delivery of relevant ions from biomaterials, BE.EP.DR

Abstract

In this project is proposed to modify the surface of Bioglass 45S5 with calcium ions employing ion exchange method and short duration heat treatment. By using these procedures are expected to change the chemical composition and microstructural properties of glass surface. Previous studies on surface modification of 45S5 Bioglass has demonstrated an acceleration of the kinetics of formation of the calcium phosphate layer on the surface of the modified bioglass. In addition, the ion exchange method for promoting the enrichment with calcium ions can allow the study of surface properties with a composition that would not be obtained by direct synthesis by melt-quenching method. Short duration heat treatment, in turn, on the surface enriched in Ca+2 can induce the formation of domain calcium-rich domains that play a role as preferential nucleation centers for apatite. By combining these two methods for glass surface modification is possible to design of surfaces, modulating their properties of bioactivity and osteoinduction. Another aim of this project is studying the effects of niobium oxide on the glass structure, bioactivity, and mechanical properties. The study of changes in the composition of 45S5 bioglass with niobium oxide is promising, and it can contribute to the expansion of knowledge of the biocompatible properties of Nb2O5 in bioglasses.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOPES, J. H.; FRANCA, C. G.; BEPPU, M. M. Development and characterization of membranes derived from SF/GLY/58S hybrid xerogels for the release of inorganic ions as an osteogenic stimulus for bone regeneration. EUROPEAN POLYMER JOURNAL, v. 116, p. 425-437, JUL 2019. Web of Science Citations: 0.

LOPES, JOAO HENRIQUE; BARRETO FONSECA, EMANUELLA MARIA; MAZALI, ITALO O.; MAGALHAES, ALVICLER; LANDERS, RICHARD; BERTRAN, CELSO APARECIDO. Facile and innovative method for bioglass surface modification: Optimization studies. Materials Science & Engineering C-Materials for Biological Applications, v. 72, p. 86-97, MAR 1 2017. Web of Science Citations: 4.

LOPES, JOAO HENRIQUE; MAGALHAES, ALVICLER; MAZALI, ITALO ODONE; BERTRAN, CELSO APARECIDO. Effect of Niobium Oxide on the Structure and Properties of Melt-Derived Bioactive Glasses. Journal of the American Ceramic Society, v. 97, n. 12, p. 3843-3852, DEC 2014. Web of Science Citations: 14.

LOPES, JOAO H.; MAZALI, ITALO ODONE; LANDERS, RICHARD; BERTRAN, CELSO A. Structural Investigation of the Surface of Bioglass 45S5 Enriched with Calcium Ions. Journal of the American Ceramic Society, v. 96, n. 5, p. 1464-1469, MAY 2013. Web of Science Citations: 12.