| Grant number: |
10/05394-9
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| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): |
October 01, 2010
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| Effective date (End): |
January 19, 2015
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| Field of knowledge: | Physical Sciences and Mathematics
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Chemistry
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Physical-Chemistry |
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| Principal Investigator: | Celso Aparecido Bertran |
| Grantee: | João Henrique Lopes |
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| Home Institution: |
Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
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| Associated scholarship(s): | 13/12376-5 - Bone formation controlled by biologically active inorganic ions: investigation of the role and controlled delivery of relevant ions from biomaterials,
BE.EP.DR
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Abstract
In this project is proposed to modify the surface of Bioglass 45S5 with calcium ions employing ion exchange method and short duration heat treatment. By using these procedures are expected to change the chemical composition and microstructural properties of glass surface. Previous studies on surface modification of 45S5 Bioglass has demonstrated an acceleration of the kinetics of formation of the calcium phosphate layer on the surface of the modified bioglass. In addition, the ion exchange method for promoting the enrichment with calcium ions can allow the study of surface properties with a composition that would not be obtained by direct synthesis by melt-quenching method. Short duration heat treatment, in turn, on the surface enriched in Ca+2 can induce the formation of domain calcium-rich domains that play a role as preferential nucleation centers for apatite. By combining these two methods for glass surface modification is possible to design of surfaces, modulating their properties of bioactivity and osteoinduction. Another aim of this project is studying the effects of niobium oxide on the glass structure, bioactivity, and mechanical properties. The study of changes in the composition of 45S5 bioglass with niobium oxide is promising, and it can contribute to the expansion of knowledge of the biocompatible properties of Nb2O5 in bioglasses.
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Scientific publications
(7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, V, FILIPE;
SOUZA, LUCAS P.;
MARTINS, THAIS M. M.;
LOPES, JOAO H.;
MATTOS, BRUNO D.;
MARIANO, MARCOS;
PINHEIRO, IVANEI F.;
VALVERDE, THALITA M.;
LIVI, SEBASTIEN;
CAMILLI, JOSE A.;
GOES, ALFREDO M.;
GOUVEIA, RUBIA F.;
LONA, LILIANE M. F.;
ROJAS, ORLANDO J.
Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration.
NANOSCALE,
v. 11,
n. 42,
p. 19842-19849,
NOV 14 2019.
Web of Science Citations: 0.
LOPES, JOAO H.;
SOUZA, LUCAS P.;
DOMINGUES, JULIANA A.;
FERREIRA, V, FILIPE;
HAUSEN, MOEMA DE ALENCAR;
CAMILLI, JOSE A.;
MARTIN, RICHARD A.;
DE REZENDE DUEK, ELIANA A.;
MAZALI, ITALO O.;
BERTRAN, CELSO A.
In vitro and in vivo osteogenic potential of niobium-doped 45S5 bioactive glass: A comparative study.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,
OCT 2019.
Web of Science Citations: 1.