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Bioglasses derived from 45S5: effects of Nb2O5 or surface modification with Ca2+ on the glass structure and bioactivity

Grant number: 10/05394-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2010
Effective date (End): January 19, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Celso Aparecido Bertran
Grantee:João Henrique Lopes
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):13/12376-5 - Bone formation controlled by biologically active inorganic ions: investigation of the role and controlled delivery of relevant ions from biomaterials, BE.EP.DR


In this project is proposed to modify the surface of Bioglass 45S5 with calcium ions employing ion exchange method and short duration heat treatment. By using these procedures are expected to change the chemical composition and microstructural properties of glass surface. Previous studies on surface modification of 45S5 Bioglass has demonstrated an acceleration of the kinetics of formation of the calcium phosphate layer on the surface of the modified bioglass. In addition, the ion exchange method for promoting the enrichment with calcium ions can allow the study of surface properties with a composition that would not be obtained by direct synthesis by melt-quenching method. Short duration heat treatment, in turn, on the surface enriched in Ca+2 can induce the formation of domain calcium-rich domains that play a role as preferential nucleation centers for apatite. By combining these two methods for glass surface modification is possible to design of surfaces, modulating their properties of bioactivity and osteoinduction. Another aim of this project is studying the effects of niobium oxide on the glass structure, bioactivity, and mechanical properties. The study of changes in the composition of 45S5 bioglass with niobium oxide is promising, and it can contribute to the expansion of knowledge of the biocompatible properties of Nb2O5 in bioglasses.

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, UCAS P. L.; LOPES, JOAO H.; FERREIRA, V, FILIPE; MARTIN, RICHARD A.; BERTRAN, CELSO A.; CAMILLI, JOSE A.. Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo models. Journal of Biomedical Materials Research Part A, v. 108, n. 3, . (10/05394-9, 16/24372-2)
LOPES, JOAO H.; MAZALI, ITALO ODONE; LANDERS, RICHARD; BERTRAN, CELSO A.. Structural Investigation of the Surface of Bioglass 45S5 Enriched with Calcium Ions. Journal of the American Ceramic Society, v. 96, n. 5, p. 1464-1469, . (10/05394-9)
FERREIRA, V, FILIPE; SOUZA, LUCAS P.; MARTINS, THAIS M. M.; LOPES, JOAO H.; MATTOS, BRUNO D.; MARIANO, MARCOS; PINHEIRO, IVANEI F.; VALVERDE, THALITA M.; LIVI, SEBASTIEN; CAMILLI, JOSE A.; et al. Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration. NANOSCALE, v. 11, n. 42, p. 19842-19849, . (18/12831-8, 18/16851-3, 16/09588-9, 10/05394-9)
LOPES, JOAO HENRIQUE; MAGALHAES, ALVICLER; MAZALI, ITALO ODONE; BERTRAN, CELSO APARECIDO. Effect of Niobium Oxide on the Structure and Properties of Melt-Derived Bioactive Glasses. Journal of the American Ceramic Society, v. 97, n. 12, p. 3843-3852, . (10/05394-9)
LOPES, JOAO H.; SOUZA, LUCAS P.; DOMINGUES, JULIANA A.; FERREIRA, V, FILIPE; HAUSEN, MOEMA DE ALENCAR; CAMILLI, JOSE A.; MARTIN, RICHARD A.; DE REZENDE DUEK, ELIANA A.; MAZALI, ITALO O.; BERTRAN, CELSO A.. In vitro and in vivo osteogenic potential of niobium-doped 45S5 bioactive glass: A comparative study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 108, n. 4, p. 1372-1387, . (11/17877-7, 11/09240-9, 10/05394-9, 10/00863-0)
BUENO, OTTO MAO VARGAS MACHUCA; HERRERA, CHRISTIAN LEONARDO; BERTRAN, CELSO APARECIDO; SAN-MIGUEL, MIGUEL ANGEL; LOPES, JOAO HENRIQUE. An experimental and theoretical approach on stability towards hydrolysis of triethyl phosphate and its effects on the microstructure of sol-gel-derived bioactive silicate glass. Materials Science & Engineering C-Materials for Biological Applications, v. 120, . (13/07296-2, 10/05394-9, 16/23891-6)
LOPES, JOAO HENRIQUE; BARRETO FONSECA, EMANUELLA MARIA; MAZALI, ITALO O.; MAGALHAES, ALVICLER; LANDERS, RICHARD; BERTRAN, CELSO APARECIDO. Facile and innovative method for bioglass surface modification: Optimization studies. Materials Science & Engineering C-Materials for Biological Applications, v. 72, p. 86-97, . (10/05394-9)
LOPES, JOAO HENRIQUE; MAGALHA, ALVICLER; BERTRAN, CELSO APARECIDO. orphological, structural, and in vitro bioactivity of core-shell-structured bioactive glass by multitechnical spectroscopic approac. CERAMICS INTERNATIONAL, v. 48, n. 6, p. 8039-8050, . (10/05394-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOPES, João Henrique. Bioglasses derived from 45S5: effects of Nb2O5 or surface modification with Ca2+ on the glass structure and bioactivity. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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Filed patent(s) as a result of this research project

COMPOSIÇÃO VÍTREA BIOATIVA E SEU USO PARA REGENERAÇÃO ÓSSEA BR1020150070420 - Universidade Estadual de Campinas (UNICAMP) . João Henrique Lopes; Celso Aparecido Bertran; Lucas Pereira Lopes de Souza; Italo Odone Mazali; José Angelo Camilli - March 2015, 30

BIOACTIVE VITREOUS COMPOSITION AND ITS USE FOR BONE REGENERATION PCT/BR2015/000186 - Universidade Estadual de Campinas (UNICAMP) . João Henrique Lopes; Celso Aparecido Bertran; Lucas Pereira Lopes de Souza; Italo Odone Mazali; José Angelo Camilli - December 2015, 15