Evaluation of the biological role of fatty acid synthase (FASN) enzyme in lymphatic endothelial cells stimulated by malignant cells in culture

• Grant number: 10/51090-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2010
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Edgard Graner
• Grantee: Débora Campanella Bastos
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Associated research grant: 08/57471-7 - The role of fatty acid synthase activity in apoptosis, metastasis and vasculogenesis in melanoma, AP.TEM

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BASTOS, DEBORA C.; PAUPERT, JENNY; MAILLARD, CATHERINE; SEGUIN, FABIANA; CARVALHO, MARCO A.; AGOSTINI, MICHELLE; COLETTA, RICARDO D.; NOEL, AGNES; GRANER, EDGARD. Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model. LABORATORY INVESTIGATION, v. 97, n. 2, p. 194-206, FEB 2017. (08/57471-7, 14/20832-3, 10/51090-1)

AGOSTINI, MICHELLE; ALMEIDA, LUCIANA Y.; BASTOS, DEBORA C.; ORTEGA, ROSE M.; MOREIRA, FERNANDA S.; SEGUIN, FABIANA; ZECCHIN, KARINA G.; RAPOSO, HELENA F.; OLIVEIRA, HELENA C. F.; AMOEDO, NIVEA D.; et al. The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas. MOLECULAR CANCER THERAPEUTICS, v. 13, n. 3, p. 585-595, MAR 2014. (12/25160-8, 08/57471-7, 10/51090-1)

SEGUIN, F.; CARVALHO, M. A.; BASTOS, D. C.; AGOSTINI, M.; ZECCHIN, K. G.; ALVAREZ-FLORES, M. P.; CHUDZINSKI-TAVASSI, A. M.; COLETTA, R. D.; GRANER, E.. The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. BRITISH JOURNAL OF CANCER, v. 107, n. 6, p. 977-987, SEP 4 2012. (08/57471-7, 10/51090-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BASTOS, Débora Campanella. Avaliação do papel biológico da enzima ácido graxo sintese (FASN) em células endoteliais linfáticas estimuladas ou não por células de melanoma. 2012. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.