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Evaluation of the biological role of fatty acid synthase (FASN) enzyme in lymphatic endothelial cells stimulated by malignant cells in culture

Grant number: 10/51090-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2010
Effective date (End): August 31, 2012
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Edgard Graner
Grantee:Débora Campanella Bastos
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated research grant:08/57471-7 - The role of fatty acid synthase activity in apoptosis, metastasis and vasculogenesis in melanoma, AP.TEM
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASTOS, DEBORA C.; PAUPERT, JENNY; MAILLARD, CATHERINE; SEGUIN, FABIANA; CARVALHO, MARCO A.; AGOSTINI, MICHELLE; COLETTA, RICARDO D.; NOEL, AGNES; GRANER, EDGARD. Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model. LABORATORY INVESTIGATION, v. 97, n. 2, p. 194-206, . (08/57471-7, 14/20832-3, 10/51090-1)
AGOSTINI, MICHELLE; ALMEIDA, LUCIANA Y.; BASTOS, DEBORA C.; ORTEGA, ROSE M.; MOREIRA, FERNANDA S.; SEGUIN, FABIANA; ZECCHIN, KARINA G.; RAPOSO, HELENA F.; OLIVEIRA, HELENA C. F.; AMOEDO, NIVEA D.; et al. The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas. MOLECULAR CANCER THERAPEUTICS, v. 13, n. 3, p. 585-595, . (12/25160-8, 08/57471-7, 10/51090-1)
SEGUIN, F.; CARVALHO, M. A.; BASTOS, D. C.; AGOSTINI, M.; ZECCHIN, K. G.; ALVAREZ-FLORES, M. P.; CHUDZINSKI-TAVASSI, A. M.; COLETTA, R. D.; GRANER, E.. The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. BRITISH JOURNAL OF CANCER, v. 107, n. 6, p. 977-987, . (08/57471-7, 10/51090-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BASTOS, Débora Campanella. Avaliação do papel biológico da enzima ácido graxo sintese (FASN) em células endoteliais linfáticas estimuladas ou não por células de melanoma. 2012. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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