| Grant number: | 10/16823-8 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | January 01, 2011 |
| End date: | December 31, 2011 |
| Field of knowledge: | Biological Sciences - Pharmacology - General Pharmacology |
| Principal Investigator: | Thiago Mattar Cunha |
| Grantee: | Eleonora Uchôa Carreira |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract Pain is an important health problem in our society affecting the quality of life. Furthermore, pain increases the expenses of health system which have to spend a lot of funds with analgesics and others therapies against pain. Another important point is that the most of the analgesics available are not as efficient as ideal, or result in a great number of side effects. In this context, the research and development of new pharmacology therapies for pain control such as the development of new analgesics is extremely necessary. The alpha 7 nicotinic receptors have been considered as an interesting target for the control of inflammatory pain. Indeed, the activation of these receptors by selective agonists produces analgesia in many experimental models and in humans. However, the molecular mechanisms associated with this effect are not characterized yet. This project intends to describe the possible analgesic effect of a selective alfa 7 nicotinic agonist, the choline, giving emphasis in the molecular mechanisms operating antinociception produced by the peripheral activation of these receptors. Probably, this project will open a huge perspective for the development of new therapies for pain control which is fundamental for increase the quality of life scores. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |