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Analysis of protein profile MAGE A3, p53, MDM2 and KAP-1 in malignancy identification and in the characterization of thyroid follicular lesions

Grant number: 10/11769-5
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): July 31, 2012
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Laura Sterian
Grantee:Mariana Bonjiorno Martins
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The differentiated thyroid cancer (DTC) is characterized by its clinical and pathological variety. Although relatively rare, is a real public health problem given the high prevalence of nodules in the population. Moreover, although the most CDT has good development, it is essential to identify patients at higher risk. Because of this, many patients receive an overtreatment, and unnecessary, while other patients who would benefit from more aggressive intervention or new molecular therapies slow to be recognized. Thus, the study of markers for diagnosis and prognosis is imperative. For this, there are several proteins that have been shown to differentially expressed in cancer patients. This work aims to study the protein profile of MAGE A3 antigen, p53, MDM2 and KAP1 in patients with differentiated thyroid cancer by checking for possible utility as diagnostic markers and prognosis in order to contribute to the identification of different thyroid cancers, which may lead to new treatment strategies.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINS, Mariana Bonjiorno. Analysis of protein profile MAGE A3, P53, MDM2 and KAP-1 in malignancy identification and in the characterization of thyroid follicular lesions. 2012. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas.

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