Analysis of protein profile MAGE A3, p53, MDM2 and KAP-1 in malignancy identification and in the characterization of thyroid follicular lesions

• Grant number: 10/11769-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Laura Sterian
• Grantee: Mariana Bonjiorno Martins
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The differentiated thyroid cancer (DTC) is characterized by its clinical and pathological variety. Although relatively rare, is a real public health problem given the high prevalence of nodules in the population. Moreover, although the most CDT has good development, it is essential to identify patients at higher risk. Because of this, many patients receive an overtreatment, and unnecessary, while other patients who would benefit from more aggressive intervention or new molecular therapies slow to be recognized. Thus, the study of markers for diagnosis and prognosis is imperative. For this, there are several proteins that have been shown to differentially expressed in cancer patients. This work aims to study the protein profile of MAGE A3 antigen, p53, MDM2 and KAP1 in patients with differentiated thyroid cancer by checking for possible utility as diagnostic markers and prognosis in order to contribute to the identification of different thyroid cancers, which may lead to new treatment strategies.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, MARIANA BONJIORNO; BATISTA, FERNANDO DE ASSIS; MARCELLO, MARJORY ALANA; BUFALO, NATASSIA ELENA; PERES, KARINA COLOMBERA; MORARI, ELAINE CRISTINA; SOARES, FERNANDO AUGUSTO; VASSALLO, JOSE; WARD, LAURA STERIAN. linical utility of the imunohistochemical co-expression of p53 and MDM2 in thyroid follicular lesion. ANNALS OF DIAGNOSTIC PATHOLOGY, v. 53, AUG 2021. (10/08412-8, 10/11769-5)