Inter-relationships among insulin resistance, hypothalamic dysfunction, sympathetic hyperactivity and arterial hypertension induced by high fat, high sucrose diet.

• Grant number: 10/19018-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2011
• End date: November 30, 2011
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: William Tadeu Lara Festuccia
• Grantee: Natália Mauadie Silva
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/15354-7 - Role of adipose tissue in the development of obesity and associated co-morbidities: investigation of molecular mechanism and search for alternative therapies, AP.JP

Abstract

The prevalence of obesity is drastically increasing worldwide. The excessive fat deposition mainly in visceral depots is directly associated dyslipidemia, arterial hypertension and hyperinsulinemia, all risk factors for the development of chronic diseases like type 2 diabetes and cardiovascular disease. Several studies have found a direct association between obesity induced by a high fat, high sucrose diet with sympathetic overactivity and arterial hypertension. The factors and mechanisms, however, by which excessive fat deposition results in sympathetic overactivity and arterial hypertension were not yet elucidated. White adipose tissue produces and secretes several molecules like adipokines and lipokines that act in the central nervous system modulating neural activity. The involvement of these molecules in the development of obesity related sympathetic overactivity and arterial hypertension is still to be characterized. Thus the current project aims to evaluate the time-course and inter-relationships between the development of insulin resistance and low-grade inflammation associated with obesity and sympathetic overactivity and arterial hypertension induced by a high fat, high sucrose diet.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHAAR, LAIALI J.; COELHO, ALINE; SILVA, NATALIA M.; FESTUCCIA, WILLIAM L.; ANTUNES, VAGNER R.. High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice. PHYSIOLOGICAL REPORTS, v. 4, n. 11, JUN 2016. (13/06206-0, 11/13563-8, 09/15354-7, 10/19018-9, 15/19530-5)