Fear conditioning, extinction and recall in obsessive-compulsive disorder patients pre- and post-treatment with serotonin reuptake inhibitors.

• Grant number: 11/00968-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2011
• End date: April 30, 2014
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Eurípedes Constantino Miguel Filho
• Grantee: Juliana Belo Diniz
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Obsessive-compulsive disorder (OCD) has an estimated lifetime prevalence of 3% in the general population and has been associated with significant social, professional, academic and familial burden. The serotonin reuptake inhibitors (SRI) are the first-line treatment choice for OCD. However, the mechanisms that lead to OCD symptoms improvements with the use of SRI are still unknown. In addition, a significant number of OCD patients do not improve satisfactorily with SRI treatment and, so far, it is not possible to determine beforehand which patients will not improve or which factors may explain non-response. To better understand the neurophysiologic mechanisms associated with OCD treatment, we propose the use of electro physiological measures (such as heart rate variability and skin conductance response) in paradigms of fear condition and exposure to sudden loud tones as a way to evaluate the effect of SRI in each component of the OCD behavioral chain. We aim to evaluate 15 health subjects and 30 OCD patients pre- and post treatment with SRI or placebo. We expect to observe differences in the electrophysiological measures in OCD patients compared to controls and after treatment with SRI. With these results we may determine if the SRI reduce OCD symptoms as consequence of diminishing the aversive respondent component of the OCD behavioral chain.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KARINA SOARES DE OLIVEIRA; ANA GABRIELA HOUNIE; CAROLINA CAPPI; JULIANA BELO DINIZ. Aprendizado, aquisição e extinção de medo mediados pelo fator neurotrófico derivado do cérebro, como alvos para o desenvolvimento de novos tratamentos para ansiedade. Jornal Brasileiro de Psiquiatria, v. 65, n. 3, p. 251-261, 2016-09-00. (11/00968-0, 11/21357-9, 12/09648-0)

DA CONCEICAO COSTA, DANIEL LUCAS; SHAVITT, ROSELI GEDANKE; CASTRO CESAR, RAONY CASSAB; JOAQUIM, MARINES ALVES; BORCATO, SONIA; VALERIO, CAROLINA; MIGUEL, EURIPEDES CONSTANTINO; DINIZ, JULIANA BELO. Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making. JOURNAL OF PSYCHIATRIC RESEARCH, v. 47, n. 11, p. 1700-1707, NOV 2013. (11/51485-9, 12/14070-8, 11/00968-0)

SUBIRA, MARTA; SATO, JOAO R.; ALONSO, PINO; DO ROSARIO, MARIA C.; SEGALAS, CINTO; BATISTUZZO, MARCELO C.; REAL, EVA; LOPES, ANTONIO C.; CERRILLO, ESTER; DINIZ, JULIANA B.; et al. Brain structural correlates of sensory phenomena in patients with obsessive-compulsive disorder. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, v. 40, n. 4, p. 232-240, JUL 2015. (11/21357-9, 13/00506-1, 11/00968-0, 13/22536-0, 13/10498-6)

REIMER, ADRIANO EDGAR; DE OLIVEIRA, AMANDA RIBEIRO; DINIZ, JULIANA BELO; HOEXTER, MARCELO QUEIROZ; CHIAVEGATTO, SILVANA; BRANDAO, MARCUS LIRA. Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors. Behavioural Brain Research, v. 292, p. 370-380, OCT 1 2015. (12/09648-0, 11/21357-9, 11/00041-3, 11/00968-0)

DINIZ, JULIANA B.; COSTA, DANIEL L. C.; CASSAB, RAONY C. C.; PEREIRA, CARLOS A. B.; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G.. The impact of comorbid body dysmorphic disorder on the response to sequential pharmacological trials for obsessive-compulsive disorder. JOURNAL OF PSYCHOPHARMACOLOGY, v. 28, n. 6, p. 603-611, JUN 2014. (11/00968-0, 11/21357-9, 08/57896-8)