Involvement of the knin B1 receptor in melanoma development and metastasis

• Grant number: 11/02144-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2011
• End date: March 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Claudio Miguel da Costa Neto
• Grantee: Andrea Gutierrez Maria
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Malignant melanoma is between the cancer types that most have been increased in the last decades. When it is early detected, chances of cure through surgical excisions with secure margins are high. However, advanced cases of melanoma are resistant to all types of therapies; thus, one of the most challenges for melanoma research is the identification of molecular targets to further develop new treatment strategies.The ability to blockade the development of a tumor, depends on better understanding of cellular and molecular pathways that operate in the tumor microenvironment. A chronic and persistent inflammation contributes to cancer development, and, even tumors that are not epidemiologically linked to pathogens, they present inflammatory components in their microenvironment. The Kallicrein-Kinin system (KKS) is responsible for many biological effects like vasodilatation, modulation of pain and inflammation, capillary permeability increase, contraction and relaxation of the smooth muscles and cell proliferation. The kinin B1 receptor is well related to inflammatory processes, but the involvement of the KKS in cancer development is not well described in the literature. A recent study about the expression of the B1 and B2 receptors in lung cancer showed a modulation on the expression of these receptors in different subtypes of lung cancer. Regarding to melanoma, studies relating the involvement of the KKS in melanoma development is still not available. Thus, the aim of this work is evaluate the participation of the kinin B1 receptor as well as cell signaling pathways that might be involved in melanoma progression and metastasis. Our results might contribute to the identification of genetic mechanisms and signaling pathways that drive tumor progression, which is extremely important for designing rational therapies in the future.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARIA, ANDREA GUTIERREZ; DILLEMBURG-PILLA, PATRICIA; DURAND, MARINA DE TOLEDO; FLORIANO, ELAINE MEDEIROS; MANFIOLLI, ADRIANA OLIVEIRA; RAMOS, SIMONE GUSMAO; PESQUERO, JOAO BOSCO; NAHMIAS, CLARA; COSTA-NETO, CLAUDIO M.. Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response. FRONTIERS IN PHARMACOLOGY, v. 10, SEP 25 2019. (11/02144-4, 10/13346-4, 12/20148-0)

MARIA, ANDREA G.; DILLENBURG-PILLA, PATRICIA; REIS, ROSANA I.; FLORIANO, ELAINE M.; TEFE-SILVA, CRISTIANE; RAMOS, SIMONE G.; PESQUERO, JOAO B.; NAHMIAS, CLARA; COSTA-NETO, CLAUDIO M.. Host kinin B1 receptor plays a protective role against melanoma progression. SCIENTIFIC REPORTS, v. 6, FEB 22 2016. (11/02144-4, 10/13346-4, 12/20148-0)