Evaluation of seric and urinary CA 19-9 and TGF ß1 in a rat model of complete and /or partial ureteral obstruction

• Grant number: 11/06180-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2011
• End date: May 31, 2012
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Francisco Tibor Dénes
• Grantee: Matheus Gesualdo Bartolamei
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

According to its intensity, ureteral obstruction may cause progressive anatomic and functional damage to the kidney. Urinary markers produced by the kidney or by its transitional epithelium are abnormally over expressed in the setting of renal damage, reflecting the gravity of urinary tract obstruction. Quantitative measure of these markers might allow the separation of patients with significant functional and anatomic urinary tract obstruction from those with non-obstructive dilatation of the urinary tract. In a rat model, seric and urinary markers (TGF ß1 and CA 19-9) will be evaluated after partial (unilateral vs bilateral) and complete surgically created ureteral obstruction.The aim of this study is to evaluate the use of these markers as indicators of significant urinary tract obstruction and subsequent renal damage, provided that low-cost and avaliability of these markers might help their incorporation in daily clinical assessment for initial evaluation of suspect urinary obstruction, during clinical follow-up of pediatric and adult hydronephrosis, and also in cases of moderated, intermittent or persistent post-surgical hydronephrosis.