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Evaluation of seric and urinary Ca 19-9 and TGF ß1 in a rat model of complete and/or partial ureteral obstruction

Grant number: 11/50201-7
Support type:Regular Research Grants
Duration: April 01, 2011 - March 31, 2013
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Francisco Tibor Dénes
Grantee:Francisco Tibor Dénes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


According to its intensity, ureteral obstruction may cause progressive anatomic and functional damage to the kidney. Urinary markers produced by the kidney or by its transitional epithelium are abnormally over expressed in the setting of renal damage, reflecting the gravity of urinary tract obstruction. Quantitative measure of these markers might allow the separation of patients with significant functional and anatomic urinary tract obstruction from those with non-obstructive dilatation of the urinary tract. In a rat model, seric and urinary markers (TGF ß1 and CA 19-9) will be evaluated after partial (unilateral vs bilateral) and complete surgically created ureteral obstruction. The aim of this study is to evaluate the use of these markers as indicators of significant urinary tract obstruction and subsequent renal damage, provided that low-cost and availability of these markers might help their incorporation in daily clinical assessment for initial evaluation of suspect urinary obstruction, during clinical follow-up of pediatric and adult hydronephrosis, and also in cases of moderated, intermittent or persistent post-surgical hydronephrosis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, ROBERTO IGLESIAS; DENES, FRANCISCO TIBOR; BARTOLAMEI, MATHEUS GESUALDO; REIS, SABRINA; SANCHES, TALITA ROJAS; LEITE, KATIA RAMOS; SROUGI, MIGUEL; SEGURO, ANTONIO CARLOS. Serum and Urinary Values of CA 19-9 and TGF beta 1 in a Rat Model of Partial or Complete Ureteral Obstruction. EUROPEAN JOURNAL OF PEDIATRIC SURGERY, v. 25, n. 6, p. 513-519, DEC 2015. Web of Science Citations: 5.

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