Energy expenditure and substrate oxidation in patients with hematological malignancy

• Grant number: 11/04057-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Belinda Pinto Simoes
• Grantee: Paula Cristina Galati
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The gradual loss present in most patients with cancer can be partly attributed to changes in resting energy expenditure. The hypermetabolism of these patients can significantly contribute to a negative energy balance. Furthermore, studies have suggested that cancer patients have alterations in the metabolism of macronutrients. To describe and compare the nutritional status, resting energy expenditure and substrate oxidation in patients with acute leukemia, before and after the first cycle of chemotherapy and in healthy volunteers. Nutritional assessment will be used to record three-day food, anthropometric data (weight, height, BMI) and body composition by bioelectrical impedance. Indirect calorimetry analysis and nitrogen excreted in 24 hours will be used to evaluation of resting energy expenditure and substrate utilization. Results are expressed as mean and standard deviation. Analysis of the differences within and between groups (control and chemotherapy) is made by nonparametric test. (AU)