This study aims to use alternative means to study the metabolism of monensin A, an important antibiotic ionophore used in veterinary applications in Brazil and the world against coccidiosis, by applying techniques employing biomimetic metabolism (metalloporphyrin and complex salen) and employing biological (endophytes). This will be developed and validated chromatographic methods (HPLC-MS,HPLC-MS/MS) for analyzing the products of metabolism. It is still part of the objectives of this project to obtain more active metabolites possibly preparative scale. Within this overall context this project aims to implement a work platform that will allow preclinical studies involving the metabolism of natural products groups included in the project "Development of a Platform for the Study of Metabolism In Vivo and In Vitro Products Natural System A Need for Pre-Clinical Trials. "
News published in Agência FAPESP Newsletter about the scholarship: