Investigation of the secondary metabolism of two fungal strains from the marine environment

• Grant number: 11/08064-2
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2011
• Effective date (End): June 30, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Laura Pavan Ióca
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The present investigation aims to obtain knowledge on the secondary metabolism of two fungal strains, isolated from an ascidian, Didemnum ligulum. After strains growth in artificial media and obtation of the respective crude extracts, separation steps will be performed in order to isolate pure compounds to be identified using spectroscopic techniques. The biological activity of the isolated compounds will be evaluated in the same assays in which crude extracts presented activity.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAURA P. IÓCA; STELAMAR ROMMINGER; MARIO F. C. SANTOS; KARIN F. BANDEIRA; FABIANA T. RODRIGUES; MIRIAM H. KOSSUGA; KAREN J. NICACIO; EVERTON L. F. FERREIRA; RAQUEL P. MORAIS-URANO; MESSIAS S. PASSOS; LUCIANA K. KOHN; CLARICE W. ARNS; LARA D. SETTE; ROBERTO G. S. BERLINCK. A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE. Química Nova, v. 39, n. 6, p. 720-731, Jul. 2016. Web of Science Citations: 1.

IOCA, LAURA P.; ALLARD, PIERRE-MARIE; BERLINCK, ROBERTO G. S. Thinking big about small beings - the (yet) underdeveloped microbial natural products chemistry in Brazil. NATURAL PRODUCT REPORTS, v. 31, n. 5, p. 646-675, 2014. Web of Science Citations: 12.

GALLAGHER, KELLEY A.; RAUSCHER, KRISTIN; IOCA, LAURA PAVAN; JENSEN, PAUL R. Phylogenetic and Chemical Diversity of a Hybrid-IsoprenoidProducing Streptomycete Lineage. Applied and Environmental Microbiology, v. 79, n. 22, p. 6894-6902, NOV 2013. Web of Science Citations: 10.