| Full text | |
| Author(s): Show less - |
Laura P. Ióca
[1]
;
Stelamar Romminger
;
Mario F. C. Santos
[3]
;
Karin F. Bandeira
[4]
;
Fabiana T. Rodrigues
[5]
;
Miriam H. Kossuga
[6]
;
Karen J. Nicacio
[7]
;
Everton L. F. Ferreira
[8]
;
Raquel P. Morais-Urano
[9]
;
Messias S. Passos
[10]
;
Luciana K. Kohn
[11]
;
Clarice W. Arns
[12]
;
Lara D. Sette
[13]
;
Roberto G. S. Berlinck
[14]
Total Authors: 14
|
| Affiliation: Show less - | [1] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[3] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[4] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[5] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[6] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[7] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[8] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[9] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[10] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
[11] Universidade de São Francisco - Brasil
[12] Universidade Estadual de Campinas. Instituto de Biologia. Laboratório de Virologia - Brasil
[13] Universidade Estadual Paulista Júlio de Mesquita Filho. Instituto de Biociências. Departamento de Bioquímica e Microbiologia - Brasil
[14] Universidade de São Paulo. Instituto de Química de São Carlos - Brasil
Total Affiliations: 14
|
| Document type: | Journal article |
| Source: | Química Nova; v. 39, n. 6, p. 720-731, 2016-07-00. |
| Abstract | |
The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and 1H NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2-dimethyl-4-chromanone is herein reported for the first time as a natural product. (AU) | |
| FAPESP's process: | 11/08064-2 - Investigation of the secondary metabolism of two fungal strains from the marine environment |
| Grantee: | Laura Pavan Ióca |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 08/00331-9 - Use of microbial co-cultures towards the production and discovery of bioactive natural products |
| Grantee: | Miriam Harumi Kossuga |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/23153-7 - Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms |
| Grantee: | Raquel Peres de Morais Urano |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/50190-2 - Investigation of metabolic and biotechnological potential of marine organisms in bioremediation processes and for the production of substances with anti-viral, anti-inflammatory and anti-Leishmania activities (Marine Biodiversity) |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |