| Full text | |
| Author(s): Show less - |
Laura P. Ióca
;
Stelamar Romminger
;
Mario F. C. Santos
;
Karin F. Bandeira
;
Fabiana T. Rodrigues
;
Miriam H. Kossuga
;
Karen J. Nicacio
;
Everton L. F. Ferreira
;
Raquel P. Morais-Urano
;
Messias S. Passos
;
Luciana K. Kohn
;
Clarice W. Arns
;
Lara D. Sette
;
Roberto G. S. Berlinck
Total Authors: 14
|
| Document type: | Journal article |
| Source: | Química Nova; v. 39, n. 6, p. 720-731, Jul. 2016. |
| Web of Science Citations: | 1 |
| Abstract | |
The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and 1H NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2-dimethyl-4-chromanone is herein reported for the first time as a natural product. (AU) | |
| FAPESP's process: | 10/50190-2 - Investigation of metabolic and biotechnological potential of marine organisms in bioremediation processes and for the production of substances with anti-viral, anti-inflammatory and anti-Leishmania activities (Marine Biodiversity) |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support type: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 08/00331-9 - Use of microbial co-cultures towards the production and discovery of bioactive natural products |
| Grantee: | Miriam Harumi Kossuga |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 13/23153-7 - Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms |
| Grantee: | Raquel Peres de Morais Urano |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support type: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 11/08064-2 - Investigation of the secondary metabolism of two fungal strains from the marine environment |
| Grantee: | Laura Pavan Ióca |
| Support type: | Scholarships in Brazil - Scientific Initiation |