Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE

Full text
Author(s):
Show less -
Laura P. Ióca ; Stelamar Romminger ; Mario F. C. Santos ; Karin F. Bandeira ; Fabiana T. Rodrigues ; Miriam H. Kossuga ; Karen J. Nicacio ; Everton L. F. Ferreira ; Raquel P. Morais-Urano ; Messias S. Passos ; Luciana K. Kohn ; Clarice W. Arns ; Lara D. Sette ; Roberto G. S. Berlinck
Total Authors: 14
Document type: Journal article
Source: Química Nova; v. 39, n. 6, p. 720-731, Jul. 2016.
Web of Science Citations: 1
Abstract

The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and 1H NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2-dimethyl-4-chromanone is herein reported for the first time as a natural product. (AU)

FAPESP's process: 10/50190-2 - Investigation of metabolic and biotechnological potential of marine organisms in bioremediation processes and for the production of substances with anti-viral, anti-inflammatory and anti-Leishmania activities (Marine Biodiversity)
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 08/00331-9 - Use of microbial co-cultures towards the production and discovery of bioactive natural products
Grantee:Miriam Harumi Kossuga
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/23153-7 - Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms
Grantee:Raquel Peres de Morais Urano
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 11/08064-2 - Investigation of the secondary metabolism of two fungal strains from the marine environment
Grantee:Laura Pavan Ióca
Support type: Scholarships in Brazil - Scientific Initiation