Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms

• Grant number: 13/23153-7
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): March 01, 2014
• Effective date (End): February 28, 2017
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Raquel Peres de Morais Urano
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

This research project aims to discover bioactive and structurally novel secondary metabolites from marine and endophytic microorganisms taxonomically selected, using dereplication strategies. Chemical investigation of crude extracts produced by unusual microbial strains will be performed after bioassays and HPLC-PDA-MS evaluation. Dereplication using MarinLit, Dictionary of Natural Products and Scifinder will be strategically employed for the finding of new bioactive compounds. Pure substances will be identified by analysis of spectroscopic data and further evaluated using bioassays in order to determine biological activity profiles. This project aims to explore yet poorly investigated microbial sources towards the discovery of compounds which might serve as models for drug development.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; BATISTA, JR., JOAO M.; SILVA, THAYNA DE SOUZA; DOS SANTOS, RAQUEL ALVES; MARTINS, CARLOS H. G.; LIRA, SIMONE P.; DA CUNHA, MARCOS G.; TRIVELLA, DANIELA B. B.; GRAZZIA, NATHALIA; GOMES, NATALIA E. S.; GADELHA, FERNANDA; MIGUEL, DANILO C.; CAUZ, ANA CAROLINA G.; BROCCHI, MARCELO; BERLINCK, ROBERTO G. S. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. Web of Science Citations: 0.

LAURA P. IÓCA; STELAMAR ROMMINGER; MARIO F. C. SANTOS; KARIN F. BANDEIRA; FABIANA T. RODRIGUES; MIRIAM H. KOSSUGA; KAREN J. NICACIO; EVERTON L. F. FERREIRA; RAQUEL P. MORAIS-URANO; MESSIAS S. PASSOS; LUCIANA K. KOHN; CLARICE W. ARNS; LARA D. SETTE; ROBERTO G. S. BERLINCK. A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE. Química Nova, v. 39, n. 6, p. 720-731, Jul. 2016. Web of Science Citations: 1.