| Full text | |
| Author(s): Show less - |
Rodriguez, Julie P. G.
[1]
;
Bernardi, Darlon I.
[1]
;
Gubiani, Juliana R.
[1]
;
de Oliveira, Juliana Magalhaes
[2]
;
Morais-Urano, Raquel P.
[1]
;
Bertonha, Ariane F.
[1]
;
Bandeira, Karin F.
[1]
;
Bulla, Jairo I. Q.
[1]
;
Sette, Lara D.
[3]
;
Ferreira, Antonio G.
[2]
;
Batista, Jr., Joao M.
[4]
;
Silva, Thayna de Souza
[5]
;
dos Santos, Raquel Alves
[5]
;
Martins, Carlos H. G.
[5]
;
Lira, Simone P.
[6]
;
da Cunha, Marcos G.
[7]
;
Trivella, Daniela B. B.
[7]
;
Grazzia, Nathalia
[8]
;
Gomes, Natalia E. S.
[8]
;
Gadelha, Fernanda
[8]
;
Miguel, Danilo C.
[8]
;
Cauz, Ana Carolina G.
[8]
;
Brocchi, Marcelo
[8]
;
Berlinck, Roberto G. S.
[1]
Total Authors: 24
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro, Avenida 24-A, 1515, Rio Claro, SP - Brazil
[4] Univ Fed Sao Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[5] Univ Franca, Nucleo Pesquisa Ciencia & Tecnol, Ave Dr Armando Salles Oliveira, 201 Pq Univ, BR-14404600 Franca, SP - Brazil
[6] Univ Sao Paulo, Dept Ciencias Exatas, Escola Super Agr Luiz de Queiroz, Agron, Ave Padua Dias 11, CP 9, BR-13418900 Piracicaba, SP - Brazil
[7] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil
[8] Univ Estadual Campinas, Inst Biol, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 83, n. 1, p. 55-65, JAN 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites. (AU) | |
| FAPESP's process: | 13/23153-7 - Use of dereplication for the discovery of new bioactive natural products from marine and endophytic microorganisms |
| Grantee: | Raquel Peres de Morais Urano |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/21341-9 - Hydrophilic and bioactive secondary metabolites produced by filamentous fungi |
| Grantee: | Darlon Irineu Bernardi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer |
| Grantee: | Juliana Regina Gubiani |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 16/16033-3 - Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis |
| Grantee: | Jairo Iván Quintana Bulla |
| Support Opportunities: | Scholarships in Brazil - Doctorate |